Glutathione status in liver and plasma during development of biliary cirrhosis after bile duct ligation
Glutathione status in liver and plasma during development of biliary cirrhosis after bile duct ligation
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DOI：
10.1007/s004330050100
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发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Matern, S
中科院分区：
文献类型：
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作者：
Purucker, E;Winograd, R;Matern, S
我们对还原型谷胱甘肽(GSH)和氧化型谷胱甘肽(GSSG)在肝硬变发展过程中的变化知之甚少。因此，我们研究了大鼠胆管结扎后肝硬变过程中谷胱甘肽氧化还原系统的变化。比较胆总管结扎大鼠和假手术对照组大鼠术后6、24 h、5、15、23、38天肝脏和血浆中GSH、GSSG含量的变化。与对照组(x+/-SD：6.07+/-0.52mU/g湿重)相比，胆管结扎后24小时(+37%)和5天(+53%)肝脏GSH显著升高。此后谷胱甘肽持续下降至4.25+/-0.64 mU/g(-31%；P
We do not know much about the changes that occur in reduced (GSH) and oxidized (GSSG) glutathione in the development of liver cirrhosis. There fore, we investigated the glutathione redox system during development of liver cirrhosis after bile-duct ligation in rats. We compared the GSH and GSSG content of liver and plasma between bile-duct-ligated rats and sham-operated controls 6 and 24 h and 5, 15, 23, and 38 days after operation. Compared to con controls (x+/-SD: 6.07+/-0.52 mu mol/g wet wt.), liver GSH significantly increased 24 h (+37%) and 5 days (+53%) after bile-duct ligation. Thereafter, GSH continuously declined to 4.25+/-0.64 mu mol/g (-31%; P