Duplication is more common among laterally transferred genes than among indigenous genes.
Duplication is more common among laterally transferred genes than among indigenous genes.
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DOI：
10.1186/gb-2003-4-8-r48
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发表时间：
2003
期刊：
影响因子：
12.3
通讯作者：
Berg OG
中科院分区：
文献类型：
--
作者：
Hooper SD;Berg OG
使用组合方法和基因树的方法，一些建议的横向转移基因已被确定，其核苷酸组成和重复的频率进行了研究。最近的发展，在旁系同源进化的理解，促使重点不仅对明显有利的基因，但也对基因，可以被认为有一个微弱的或零星的影响，对生物体的生存。在这里，我们研究了一类基因的复制行为，可以被认为是在基因组中主要是瞬时的，即横向转移基因。使用组合方法和基因树的方法，我们确定了一些建议的横向转移基因，并研究其核苷酸组成和重复频率。结果发现，重复显着过度代表潜在的横向转移基因相比，土著的。此外，发现潜在的横向转移基因的GC 3分布在一些基因组中基本上是均匀的，这表明从广泛的供体输入。讨论的结果不是在一个上下文中强烈优化的既定基因，而是基因与弱或辅助功能。因此，复制的重要性可能取决于弱基因的变异性和可用性，而弱基因的新功能可能会被发现。因此，横向转移可能通过将主要功能较弱或没有功能的外源基因引入基因组来加速复制的进化过程。
Using both a compositional method and a gene-tree approach, a number of proposed laterally transferred genes have been identified and their nucleotide composition and frequency of duplication studied. Recent developments in the understanding of paralogous evolution have prompted a focus not only on obviously advantageous genes, but also on genes that can be considered to have a weak or sporadic impact on the survival of the organism. Here we examine the duplicative behavior of a category of genes that can be considered to be mostly transient in the genome, namely laterally transferred genes. Using both a compositional method and a gene-tree approach, we identify a number of proposed laterally transferred genes and study their nucleotide composition and frequency of duplication. It is found that duplications are significantly overrepresented among potential laterally transferred genes compared to the indigenous ones. Furthermore, the GC3 distribution of potential laterally transferred genes was found to be largely uniform in some genomes, suggesting an import from a broad range of donors. The results are discussed not in a context of strongly optimized established genes, but rather of genes with weak or ancillary functions. The importance of duplication may therefore depend on the variability and availability of weak genes for which novel functions may be discovered. Therefore, lateral transfer may accelerate the evolutionary process of duplication by bringing foreign genes that have mainly weak or no function into the genome.
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影响因子：
10.7
作者：
Berg, OG;Kurland, CG
通讯作者：
Kurland, CG
影响因子：
3.9
作者：
Lawrence, JG;Ochman, H
通讯作者：
Ochman, H
影响因子：
10.7
作者：
Nesbo, CL;L'Haridon, S;Doolittle, WF
通讯作者：
Doolittle, WF
影响因子：
64.8
作者：
Perna, NT;Plunkett, G;Blattner, FR
通讯作者：
Blattner, FR
影响因子：
12.3
作者：
Kondrashov FA;Rogozin IB;Wolf YI;Koonin EV
通讯作者：
Koonin EV