Catechols as Membrane Anion Transporters
Catechols as Membrane Anion Transporters
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DOI：
10.1021/ja809733c
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发表时间：
2009-02-25
影响因子：
15
通讯作者：
Davis, Jeffery T.
中科院分区：
文献类型：
--
作者：
Berezin, Sofya Kostina;Davis, Jeffery T.
我们报道了一种两亲性的双儿茶酚（3）作为跨膜阴离子转运蛋白。活性取决于邻苯二酚的取代和两亲性。我们还描述了一种脂质体测定法，可以很容易地测量阴离子转运选择性。该测定揭示了这种两亲性双儿茶酚的阴离子转运选择性遵循霍夫迈斯特序列，其中使更容易吸附的阴离子对膜的渗透性增加3。
We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.