OSTEOLATHYRISM IN THE RAT - AN X-RAY DIFFRACTION STUDY OF COLLAGEN FROM NORMAL AND LATHYRITIC RATS
OSTEOLATHYRISM IN THE RAT - AN X-RAY DIFFRACTION STUDY OF COLLAGEN FROM NORMAL AND LATHYRITIC RATS
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DOI：
10.1148/82.1.67
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发表时间：
1964-01-01
期刊：
影响因子：
19.7
通讯作者：
KUNDEL, HL
中科院分区：
文献类型：
--
作者：
KUNDEL, HL
本文简要回顾了lathyrism的历史，并介绍了大鼠骨关节炎的放射学和病理学方面。的生化和生物物理证据支持的概念，lathyrogens通过阻断胶原分子内交联的作用。正常胶原蛋白和乳酸胶原蛋白在干燥状态下是相同的。当与正常胶原相比时，在乳酸的最大水合条件下，间距可能增加。这可能表明，由lathyrogen分子内键的阻断允许胶原分子中的链比正常情况下更宽的分离。
The historical aspects of lathyrism are briefly reviewed, and the radiologic and pathologic aspects of osteolathyrism in the rat are presented. The biochemical and biophysical evidence supporting the concept that the lathyrogens act by blocking intramolecular cross linking in collagen is presented. Normal and lathyritic collagen are identical in the dry state. There may be an increase in the spacing under conditions of maximal hydration of the lathyritic when compared to the normal collagen. This may indicate that the blocking of intramolecular bonds by the lathyrogen allows wider separation of the chains in the collagen molecule than normal.