Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity
Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity
复制标题
DOI：
10.1016/j.bmc.2005.08.003
复制
发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Matsuda, H;Ando, S;Yoshikawa, M
用80%丙酮水提物对脂多糖（LPS）激活小鼠腹腔巨噬细胞产生一氧化氮（NO）有抑制作用。通过生物测定指导分离，两种二芳基庚烷[7-(4”-羟基-3”-甲氧基苯基-l-苯基庚烷-4-en-3- 1和3,5-二羟基-1,7-二苯庚烷]和一种黄酮醇成分（高良姜素）显著抑制lps诱导的NO生成，IC50值为33-62 μ M.为了阐明二芳基庚烷的构效关系，研究莪术中相关二芳基庚烷。结果表明，1-7位的双键或烯酮部分对活性有重要影响。(c) 2005 Elsevier Ltd版权所有。
The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages. Through bioassay-guided separation, two diarylheptanoids [7-(4"-hydroxy-3"-methoxyphenyl-l-phenylhept-4-en-3-one and 3,5-dihydroxy-1,7-diphenylheptane] and a flavonol constituent (galangin) Substantially inhibited LPS-induced NO production with IC50 values of 33-62 mu M. To clarify structure-activity relationships of diarylheptanoids, related diarylheptanoids from Curcuma Zedoaria were examined. Results indicate that the double bond or enone moiety at the 1-7 positions is important for the activity. (c) 2005 Elsevier Ltd. All rights reserved.