Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma
Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma
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DOI：
10.1056/nejmoa0806604
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发表时间：
2008-11-06
影响因子：
158.5
通讯作者：
Demenais, Florence
中科院分区：
文献类型：
--
作者：
Bouzigon, Emmanuelle;Corda, Eve;Demenais, Florence
背景：一项全基因组关联研究显示染色体17q21变异与哮喘风险增加相关。为了阐明这个基因座和疾病之间的关系，我们研究了一个大的，以家庭为基础的数据集，包括广泛的表型和环境数据的遗传学和环境的流行病学研究哮喘。方法：我们测试了36个单核苷酸多态性（SNP）在17q21区域的1511名受试者从372个家庭与哮喘。我们还根据哮喘发作时的年龄和早期暴露于环境烟草烟雾来检测遗传异质性。
Background: A genomewide association study has shown an association between variants at chromosome 17q21 and an increased risk of asthma. To elucidate the relationship between this locus and disease, we examined a large, family-based data set that included extensive phenotypic and environmental data from the Epidemiological Study on the Genetics and Environment of Asthma.Methods: We tested 36 single-nucleotide polymorphisms (SNPs) in the 17q21 region in 1511 subjects from 372 families for an association with asthma. We also tested for genetic heterogeneity according to the age at the onset of asthma and exposure to environmental tobacco smoke in early life.Results: Eleven SNPs were significantly associated with asthma (P