THE EFFECT OF DARK REARING ON THE TIME COURSE OF THE CRITICAL PERIOD IN CAT VISUAL-CORTEX
THE EFFECT OF DARK REARING ON THE TIME COURSE OF THE CRITICAL PERIOD IN CAT VISUAL-CORTEX
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DOI：
10.1016/0165-3806(91)90001-y
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发表时间：
1991-02-22
期刊：
影响因子：
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通讯作者：
MOWER, GD
中科院分区：
文献类型：
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作者：
MOWER, GD
为探讨暗饲养对不同日龄单眼剥夺(MD)猫出生后视皮层单眼剥夺临界期时程的影响，观察了不同日龄单眼剥夺猫的暗饲养方式。在正常发育中，可塑性(对MD的敏感性)在3周时非常低，6周时急剧上升，并在接下来的10周逐渐下降。黑暗的养育大大改变了这种发育模式，延缓了关键时期的整个时间进程。在深色饲养的猫中，可塑性在最初的12周内稳步上升，并保持在16周。这两个临界期的曲线存在交叉，因此在幼年(6周)，正常猫比深色饲养的猫更具可塑性，而在较晚的年龄(9周后)，深色饲养的猫更具可塑性。第二个实验表明，即使在一个视力正常的时期开始后，黑暗的养育也会减缓关键期的进展。在正常的关键期过后，正常饲养的猫在出生后6-8周，然后被置于黑暗中，直到5个月大，MD会产生实质性的影响。根据视觉输入的加速效应和全暗对临界期时间过程的减速效应的简单模型讨论了结果。
The effects of dark rearing on the time course of the postnatal critical period for monocular deprivation (MD) in visual cortex were determined in cats who experienced 2 days of MD at various postnatal ages. In normal development, plasticity (susceptibility to MD) was very low at 3 weeks, rose sharply at 6 weeks, and gradually declined over the next 10 weeks. This developmental profile was dramatically altered by dark rearing which slowed the entire time course of the critical period. In dark reared cats, plasticity rose steadily over the first 12 weeks, and was maintained at 16 weeks. There was a crossover of the two profiles of the critical period such that at young ages (6 weeks) normal cats were more plastic than dark reared cats while at later ages (after 9 weeks) dark reared cats were more plastic. A second experiment indicated that dark rearing slowed down the progression of the critical period even after it had been initiated by a period of normal vision. MD produced substantial effects after the normal critical period in cats who were reared normally for the first 6-8 weeks of life and then placed in darkness until 5 months of age. The results are discussed in terms of a simple model of the accelerating effect of visual input and the decelerating effect of total darkness on the time course of the critical period.