Central orexin facilitates gastric relaxation and contractility in rats
Central orexin facilitates gastric relaxation and contractility in rats
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DOI：
10.1016/s0304-3940(02)00958-8
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发表时间：
2002-11-08
影响因子：
2.5
通讯作者：
Yamamoto, T
中科院分区：
文献类型：
--
作者：
Kobashi, M;Furudono, Y;Yamamoto, T
在大鼠中检查脑池内施用合成食欲素-A（3 nmol）对胃运动的影响。食欲素，但不是一个车辆的管理引起的近端胃松弛持续超过30分钟。相，在远端胃收缩促进食欲素，但不是一个车辆的管理。在蛛网膜下水平切除双侧迷走神经的动物中未观察到远端胃的易化。在迷走神经切断的动物中观察到近端胃的松弛，但松弛的幅度显著小于完整动物。这些结果表明，中枢食欲素通过迷走神经促进远端胃运动和近端胃的舒张。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The effects of the intracisternal administration of synthetic orexin-A (3 nmol) on gastric motility were examined in rats. The administration of orexin but not a vehicle induced relaxation of the proximal stomach lasting for more than 30 min. Phasic,contractions in the distal stomach were facilitated in response to the administration of orexin but not a vehicle. Facilitation in the distal stomach was not observed in the animals which underwent the sectioning of the bilateral vagi at the subdiaphragmatic level. Relaxation of the proximal stomach was observed in vagotomized animals but the magnitude of relaxation was significantly smaller than that in intact animals. These results suggest that central orexin facilitates distal stomach motility and relaxation of the proximal stomach via vagi. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.