Choroidal and Retinal Thickness in Children With Different Refractive Status Measured by Swept-Source Optical Coherence Tomography
Choroidal and Retinal Thickness in Children With Different Refractive Status Measured by Swept-Source Optical Coherence Tomography
复制标题
扫频光学相干断层扫描测量不同屈光状态儿童的脉络膜和视网膜厚度
DOI：
10.1016/j.ajo.2016.05.008
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发表时间：
2016-08-01
影响因子：
4.2
通讯作者：
He, Xiangui
中科院分区：
文献类型：
--
作者：
Jin, Peiyao;Zou, Haidong;He, Xiangui
目得：调查脉络膜和视网膜厚度在近视，正视，远视中国儿童通过扫描源长波长optical coherence tomography.DESIGN：横断面study.METHODS：二百七十六名7-13岁的学龄儿童进行了全面的眼科检查，包括睫状肌麻痹屈光，扫描源optical coherence tomography测量。比较不同屈光状态儿童的脉络膜、视网膜、神经节细胞层和神经纤维层厚度。结果：与正视眼相比，近视眼各区域脉络膜厚度明显变薄（P <0.01），远视眼各区域脉络膜厚度明显变厚（P <0.05）。在上级旁视野和所有4个中心凹周围亚视野中，近视眼的视网膜比正视眼或远视眼的视网膜薄（P <0.05），但不同屈光度组之间的其他亚视野无显著差异（P > 0.05）。眼轴长度和屈光度与中心凹脉络膜厚度独立相关（R-2 = 0.17，P < .01），而年龄和眼压与中央凹视网膜病变独立相关。（R-2 = 0.15，P <0.01）和神经节细胞层厚度（R-2 = 0.10，P <0.01）。不同屈光状态儿童中心凹脉络膜厚度与视网膜厚度无相关性（P > .05）。结论：中国儿童脉络膜厚度与眼轴长度和屈光度密切相关，而视网膜厚度与眼轴长度和屈光度无相关性。在近视进展的早期，脉络膜变薄发生在视网膜变薄之前。(C)2016作者（S）爱思唯尔公司出版
PURPOSE: To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography.DESIGN: Cross-sectional study.METHODS: Two-hundred and seventy-six schoolchildren aged 7-13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed.RESULTS: Compared to emmetropic subjects, those with myopia had a significantly thinner choroid in all regions (P < .01), and hyperopic subjects had a thicker choroid in most regions (P < .05). The myopic retinas were thinner than those of emmetropic or hyperopic subjects in the superior parafoveal and all 4 perifoveal subfields (P < .05), but no other subfields differed significantly among different refractive groups (P > .05). The axial length and refractive diopters were independently related to central foveal choroidal thickness (R-2 = 0.17, P < .01), while age and intraocular pressure were independently associated with central fovea retinal (R-2 = 0.15, P < .01) and ganglion cell layer thicknesses (R-2 = 0.10, P < .01) after adjustment for other systematic and ocular factors. Central foveal choroidal and retinal thickness were unrelated in children of different refractive status (P > .05).CONCLUSIONS: Choroidal thickness, but not retinal thickness, correlated closely with axial length and refractive diopters in Chinese children. Choroid thinning occurs before retina thinning early in myopic progression. (C) 2016 The Author(s). Published by Elsevier Inc.