The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids
The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids
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DOI：
10.1007/bf01115004
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发表时间：
1986-02
影响因子：
4
通讯作者：
V. Preedy;P. Garlick
中科院分区：
文献类型：
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作者：
V. Preedy;P. Garlick
在禁食12 h的大鼠中，肌肉蛋白质合成速率通过再喂养1 h和通过胃内或静脉内输注氨基酸加葡萄糖混合物1 h而被刺激，但不通过静脉内输注单独的氨基酸1 h。静脉注射抗胰岛素血清抑制喂养和胃内输注的反应，但不静脉输注。结论是肌肉蛋白质合成对食物摄入的反应是由胰岛素和氨基酸协同作用介导的。
In 12 h fasted rats, rates of muscle protein synthesis were stimulated by refeeding for 1 h and by intragastric or intravenous infusion of an amino acid plus glucose mixture for 1 hr, but not by intravenous infusion of amino acids alone for 1 h. Intravenous injection of anti-insulin serum suppressed the response to feeding and to intragastric infusion, but not to intravenous infusion. It is concluded that the response of muscle protein synthesis to food intake is mediated by both insulin and amino acids acting in concert.