Accessory cell function of AIDS monocytes.
Accessory cell function of AIDS monocytes.
复制标题
艾滋病单核细胞的辅助细胞功能。
DOI：
10.1093/infdis/156.4.696
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Bovbjerg,DH
中科院分区：
文献类型：
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作者：
Murray,HW;Jacobs,JL;Bovbjerg,DH
在最近对艾滋病单核细胞的辅助细胞功能的分析中，Sei等。[1]报道，尽管循环单核细胞的绝对数量可能减少，但AIDS单核细胞表达Ia抗原（一种对T细胞活化至关重要的II类HLA分子）的能力得以保留。虽然我们没有在AIDS患者中观察到一致的单核细胞减少[2]，但机会性感染患者的外周血单核细胞除了作为正常异源T细胞最佳增殖的辅助细胞的完整能力外，基本上显示出正常的白细胞介素-1产生（表1）（表2）。这些结果与AIDS中是否存在单核细胞缺陷的问题有关，因为白细胞介素-1的分泌和总体辅助细胞功能似乎在实现有效的T细胞活化中是重要的[3，4]。结合Sei [1]的发现，我们的数据表明，尽管可能感染了人类免疫缺陷病毒[5]，艾滋病单核细胞在支持T细胞活性的能力方面没有表现出明显的内在异常。
COLLEAGUES-In a recent analysis of the accessory cell function of AIDS monocytes, Sei et al.[1] reported that although the absolute number of circulating monocytes may be decreased, the capacity of AIDS monocytes to express Ia antigen, a class II HLA molecule critical for T cell activation, is retained. Although we have not observed consistent monocytopenia in patients with AIDS [2], peripheral blood monocytes from patients with opportunistic infections essentially show normal generation of interleukin-1 (table 1) in addition to an intact capacity to act as accessory cells for the optimal proliferation of normal heterologous T cells (table 2). These results are pertinent to the issue of whether there is a monocyte defect in AIDS, because both secretion of interleukin-l and overall accessory cell function appear to be important in achieving effective T cell activation [3, 4]. Taken together with the findings of Sei [1], our data suggest that despite perhaps being infected with the human immunodeficiency virus [5], the AIDS monocyte shows no apparent intrinsic abnormality in the ability to support T cell activity.