The Escherichia coli CRISPR System Protects from λ Lysogenization, Lysogens, and Prophage Induction
The Escherichia coli CRISPR System Protects from λ Lysogenization, Lysogens, and Prophage Induction
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DOI：
10.1128/jb.00644-10
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发表时间：
2010-12-01
影响因子：
3.2
通讯作者：
Qimron, Udi
中科院分区：
文献类型：
--
作者：
Edgar, Rotem;Qimron, Udi
我们发现，噬菌体溶原化、溶原物和噬菌体诱导都是CRISPR的靶标。结果表明，基因组DNA不能免疫CRISPR系统，CRISPR系统不需要非细胞质元件，并且该系统保护噬菌体不进入和退出溶源循环。
We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, that the CRISPR system does not require noncytoplasmic elements, and that the system protects from phages entering and exiting the lysogenic cycle.