Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19(ARF)
Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19(ARF)
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DOI：
10.1002/(sici)1098-2264(199705)19:1
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发表时间：
1997-05-01
影响因子：
3.7
通讯作者：
Lassam, NJ
中科院分区：
文献类型：
--
作者：
Liu, L;Goldstein, AM;Lassam, NJ
编码细胞周期抑制剂CDKN2A的基因突变已经在一些与9p21相关的黑色素瘤中被发现。然而，许多这样的家族在CDKN2A的编码区没有显示出突变的证据。在这项研究中，我们研究了另外两个潜在的肿瘤抑制因子CDKN2B和p19（ARF）是否在家族性黑色素瘤的发展中发挥作用，它们也位于9p21区域。我们发现，在黑色素瘤易发家族中，这两个基因的编码区都没有突变，有证据表明与9p21有关联。我们的结论是，在这个染色体区域存在另一个黑色素瘤易感基因，或者CDKN2A、CDKN2B或p19（ARF）非编码区域的突变易导致黑色素瘤。(C) 1997 Wiley-Liss, Inc。
Mutations in the gene encoding the cell cycle inhibitor CDKN2A have been identified in some melanoma kindreds linked to 9p21. However, many such families show no evidence of mutations in the coding regions of CDKN2A. In this study, we examined whether two other potential tumor suppressors, CDKN2B and p19(ARF), which also map within the 9p21 region, play a role in the development of familial melanoma. We found no mutations in the coding regions of either gene in melanoma-prone families with evidence of linkage to 9p21. We conclude either that another melanoma susceptibility gene exists within this chromosomal area or that mutations in noncoding regions of CDKN2A, CDKN2B, or p19(ARF) predispose to melanoma. (C) 1997 Wiley-Liss, Inc.