[Assessment of ECG-gated myocardial SPECT analysis program with cardiac phantom and clinical data].
[Assessment of ECG-gated myocardial SPECT analysis program with cardiac phantom and clinical data].
复制标题
[利用心脏模型和临床数据评估心电门控心肌 SPECT 分析程序]。
DOI：
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发表时间：
1999
影响因子：
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通讯作者：
N. Tonami
中科院分区：
文献类型：
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作者：
T. Higuchi;J. Taki;K. Nakajima;J. Horii;M. Yamada;N. Tonami
目的
心电门控心肌 SPECT 程序 (QGS) 正在广泛使用。该程序允许通过自动检测心肌边缘来测量舒张末期容积 (EDV)、收缩末期容积 (ESV) 和射血分数 (EF)。我们使用心脏模型和临床数据评估了可重复性、准确性以及影响这些指数测量的因素。
方法
在模型研究中，我们评估了心室体积、位置、吸收、采集时间、扩大采集和预过滤对计算指标的影响。在使用 99mTc-MIBI 的临床研究中，评估了 2 名观察者之间的再现性、与左心室造影的比较以及预过滤器的效果。在201TI和123I-BMIPP的临床病例中，还通过带有各种预过滤器的QGS分析左心室容积和EF。
结果
尽管真实体模体积 (y) 和计算体积 (x) 显示出良好的线性相关性（y = 0.94x - 13.8，r = 0.999），但计算体积明显低估了 14.5-33.8%。模型周围的吸收材料导致计算体积减少 4.1-9.1%。采集时间的持续时间（每次投影 3 至 60 秒）不会影响参数的计算。随着数据收集的扩大，计算出的体积（37 毫升）大于正常采集的体积（33 毫升）。当巴特沃斯滤波器的截止频率改变时，体积和EF的这些指数在0.41周期/cm以上几乎稳定。观察者内部测量的 EDV (r = 0.998，p < 0.0001)、ESV (r = 0.998，p < 0.0001) 和 EF (r = 0.995，p < 0.0001) 具有极好的相关性。与左心室造影相比，ESV (r = 0.91，p < 0.0001)、EF (r = 0.88，p < 0.0001) 参数相关性良好，但 EDV (r = 0.78，p < 0.0001) 参数相关性一般。 The QGS program underestimated EDV, ESV and EF.
结论
带有门控 SPECT 的 QGS 程序对于计算相对体积和 EF 非常有用。然而，要计算绝对值，我们应该了解影响QGS结果的各种因素。
PURPOSES
ECG-gated myocardial SPECT program (QGS) is coming into wide use. This program permits measurement of end-diastolic volume (EDV), and end-systolic volume (ESV) and ejection fraction (EF) by automatic detection of myocardial edges. We assessed the reproducibility, accuracy, factors that affect the measurement of these indices using a cardiac phantom and clinical data.
METHODS
In the phantom study, we evaluated the effects of ventricular volume, location, absorption, acquisition time, enlarged acquisition and pre-filter on the calculated indices. In the clinical study using 99mTc-MIBI, reproducibility between 2 observers, comparison with left ventriculography and effects of pre-filter were assessed. In clinical cases of 201TI and 123I-BMIPP, left ventricular volume and EF were also analyzed by QGS with various pre-filters.
RESULTS
Although the true phantom volumes (y) and calculated volumes (x) showed an excellent linear correlation (y = 0.94x - 13.8, r = 0.999), calculated volumes were significantly under-estimated by 14.5-33.8%. An absorbent material around the phantom caused reduction in calculated volumes by 4.1-9.1%. Duration of acquisition times, 3 to 60 seconds per projection, did not influence the calculation of the parameters. With enlarged data collection, calculated volume (37 ml) was larger than that of normal acquisition (33 ml). When the cut-off frequency of Butterworth filter was changed, these indices of volume and EF were almost stable over 0.41 cycle/cm. There was an excellent correlation in intra-observer measurements for EDV (r = 0.998, p < 0.0001), ESV (r = 0.998, p < 0.0001) and EF (r = 0.995, p < 0.0001). In comparison with left ventriculography, correlation of parameters was good in ESV (r = 0.91, p < 0.0001), EF (r = 0.88, p < 0.0001), but was fair in EDV (r = 0.78, p < 0.0001). The QGS program underestimated EDV, ESV and EF.
CONCLUSION
QGS program with gated SPECT is useful to calculate relative volume and EF. However, to calculate absolute values, we should understand the various factors that affect the result of QGS.