Central Regulation of Stress Response in Cattle
Central Regulation of Stress Response in Cattle
复制标题
牛应激反应的中央调节
DOI：
10.6090/jarq.46.27
复制
发表时间：
2012
影响因子：
0.4
通讯作者：
K. Yayou
中科院分区：
文献类型：
--
作者：
K. Yayou
目前，在田间水平上，农场动物的压力的有用的和生物学上有意义的决定因素不存在，尽管压力的定量测量对于农场动物的福祉是必不可少的。在实验室水平上，使用啮齿动物，应激源引起的生理和行为变化及其中枢神经系统的调节已经得到了相当详细的阐述。然而，目前还不清楚我们是否可以将这些知识应用于啮齿动物以外的物种。因此，我们研究了几种参与调节牛应激反应的神经递质。脑室内施用的神经递质候选物的影响的检查揭示了应激反应的哪个组分被诱导或减少。因此，我们确定了几个压力诱导神经递质和一个压力减轻神经递质在牛，并建议的调节作用的神经递质的压力反应不同于其他物种，以及以啮齿动物为例。此外，对于减少压力的神经递质，催产素，我们首次表明，行为和下丘脑-垂体-肾上腺（HPA）轴的反应性急性应激源和血浆催产素浓度的基础水平和它的反应性的应激源的个体差异之间的关联。这表明，催产素可能是一个神经生物学候选人参与个体差异的压力易感性在牛。目前，我们正在研究催产素相关基因的多态性与应激易感性的个体差异之间的关联。这一知识将有助于通过遗传选择来适应环境，从而改善动物福利。
Useful and biologically meaningful determinants of stress of farm animals at the field level do not exist at present, though quantitative measurement of stress is essential for the farm animals' well-being. At laboratory level using rodents, physiological and behavioral changes induced by stressors and its regulation by the central nervous system have been elucidated in considerable detail. However, it remains unclear whether we could apply that knowledge to species other than rodents. Therefore, we studied several neurotransmitters involved in the regulation of stress response in cattle. Examination of the effects of intracerebroventricularly administered neurotransmitter candidates revealed which component of stress response was induced or reduced. Thus, we identified several stress-inducing neurotransmitters and one stress-reducing neurotransmitter in cattle, and suggested that the regulatory roles of the neurotransmitters on stress response differ from those of other species, as well exemplified by rodents. Furthermore, for the stress-reducing neurotransmitter, oxytocin, we showed for the first time the association between individual differences in behavioral and hypothalamic-pituitary-adrenal (HPA) axis reactivity to acute stressors and basal levels of plasma oxytocin concentration and its reactivity to the stressors. This suggests that oxytocin may be a neurobiological candidate involved in individual differences for stress susceptibility in cattle. Currently, we are examining the association between polymorphism of oxytocin-related genes and individual differences in stress susceptibility. This knowledge will help improve animal welfare by allowing genetic selection for adaptability to the environment.
DOI：
10.1080/00332747.1999.11024859
发表时间：
1999
期刊：
Psychiatry
影响因子：
--
作者：
R. Turner;M. Altemus;Teresa Enos;Bruce Cooper;Teresa McGuinness
通讯作者：
R. Turner;M. Altemus;Teresa Enos;Bruce Cooper;Teresa McGuinness
几种体外系统对假定的促肾上腺皮质激素促分泌剂对大鼠垂体前叶细胞效力的影响。
影响因子：
4.8
作者：
Watanabe,T;Orth,DN
通讯作者：
Orth,DN