Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis.
Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis.
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DOI：
10.1080/15384101.2017.1281486
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发表时间：
2017-03-19
期刊：
影响因子：
--
通讯作者：
Hoffman RM
中科院分区：
文献类型：
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作者：
Murata T;Mekada E;Hoffman RM
肿瘤微环境对于转移的发生至关重要。免疫缺陷小鼠中的肿瘤皮下异种移植物通常被包裹并且很少转移，这与如果原始肿瘤是转移性的则转移的原位肿瘤相反。在本报告中，我们能够重建一个转移性肿瘤的微环境，皮下共移植人宫颈癌细胞系和人宫颈癌相关的成纤维细胞（CAFs），在无胸腺小鼠，这导致在40%的动物淋巴结转移。相反，无CAFs的宫颈癌无转移发生。这些结果表明，CAFs可以克服抗转移的肿瘤环境，是一个潜在的目标，以防止转移。
The tumor microenvironment is critical for metastasis to occur. Subcutaneous xenografts of tumors in immunodeficient mice are usually encapsulated and rarely metastasize as opposed to orthotopic tumors which metastasize if the original tumor was metastatic. In the present report, we were able to reconstitute a metastatic tumor microenvironment by subcutaneously co-transplanting a human cervical cancer cell line and human cervical cancer-associated fibroblasts (CAFs), in athymic mice, which resulted in lymph node metastasis in 40% of the animals. In contrast, no metastasis occurred from the cervical cancer without CAFs. These results suggest that CAFs can overcome an anti-metastatic tumor environment and are a potential target to prevent metastasis.