Large-Scale Meta-Analysis of Human Medial Frontal Cortex Reveals Tripartite Functional Organization
Large-Scale Meta-Analysis of Human Medial Frontal Cortex Reveals Tripartite Functional Organization
复制标题
DOI：
10.1523/jneurosci.4402-15.2016
复制
发表时间：
2016-06-15
影响因子：
5.3
通讯作者：
Yarkoni, Tal
中科院分区：
文献类型：
--
作者：
de la Vega, Alejandro;Chang, Luke J.;Yarkoni, Tal
人类内侧额叶皮层（MFC）的功能组织是一个深入研究的课题。使用功能磁共振成像，MFC已与各种心理过程，包括运动功能，认知控制，情感和社会认知。然而，很少有大规模的努力，全面映射特定的心理功能，内侧额叶解剖的子区域。在这里，我们应用了一种元分析数据驱动的方法，对近10,000项fMRI研究进行了分析，以确定MFC的可分离区域，并确定哪些心理状态优先招募它们的激活。我们确定了在几个空间尺度上的元分析共激活的基础上，揭示了三个广泛的功能区沿着由2-4个较小的亚区组成的rostrocaudal轴。多变量分类分析，旨在确定最强烈的预测活动在每个区域的心理功能，揭示了一个三分之一的MFC内，每个区域显示一个相对不同的功能签名。后区优先与运动功能相关，中间区与认知控制、疼痛和情感相关，前区与奖励、社会处理和情景记忆相关。在每一个区域内，更精细的子区域显示出不同的，但更微妙的心理功能的变化。这些结果提供了关于内侧前额叶皮层功能组织的假设，可以在未来的研究中明确进行测试。
The functional organization of human medial frontal cortex (MFC) is a subject of intense study. Using fMRI, the MFC has been associated with diverse psychological processes, including motor function, cognitive control, affect, and social cognition. However, there have been few large-scale efforts to comprehensively map specific psychological functions to subregions of medial frontal anatomy. Here we applied a meta-analytic data-driven approach to nearly 10,000 fMRI studies to identify putatively separable regions of MFC and determine which psychological states preferentially recruit their activation. We identified regions at several spatial scales on the basis of meta-analytic coactivation, revealing three broad functional zones along a rostrocaudal axis composed of 2-4 smaller subregions each. Multivariate classification analyses aimed at identifying the psychological functions most strongly predictive of activity in each region revealed a tripartite division within MFC, with each zone displaying a relatively distinct functional signature. The posterior zone was associated preferentially with motor function, the middle zone with cognitive control, pain, and affect, and the anterior with reward, social processing, and episodic memory. Within each zone, the more fine-grained subregions showed distinct, but subtler, variations in psychological function. These results provide hypotheses about the functional organization of medial prefrontal cortex that can be tested explicitly in future studies.