Definitive radiotherapy for nasopharyngeal carcinoma
Definitive radiotherapy for nasopharyngeal carcinoma
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DOI：
10.1097/01.coc.0000248895.90193.7e
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发表时间：
2006-12-01
影响因子：
2.6
通讯作者：
Amdur, Robert J.
中科院分区：
文献类型：
--
作者：
Mendenhall, William M.;Morris, Christopher G.;Amdur, Robert J.
目的：我们试图报告的结果后，确定性放射治疗（RT）鼻咽癌。方法：1983年3月至2003年11月，82例患者进行治疗的目的，从0.2至22年（中位数，5年）。对在世患者的随访时间为2.8至22年（中位数为10.8年）。32例患者（39%）接受每日一次治疗，45例患者（55%）接受了超高压治疗，5例患者（6%）接受了伴随加强技术治疗。8例患者（10%）接受调强放疗。31例患者（38%）接受诱导（17例患者）或伴随（14例患者）化疗。14例患者（17%）接受了计划性颈清扫术。结果：治疗后5年的结果是：局部控制，78%;区域控制，90%;局部-区域控制，76%;无远处转移生存率，80%;原因特异性生存率，66%;生存率，57%。在多因素分析中评估了T分期、N分期、总体分期、世界卫生组织分类、分次方案和辅助化疗对各种结局的影响。只有N期和世界卫生组织的等级影响区域控制。结论：RT后治愈的可能性相对较高。虽然治愈的可能性随着分期的增加而降低，但除了N分期和WHO分级外，评价的参数均未显著影响结局。
Purpose: We sought to report the outcomes after definitive radiotherapy (RT) for nasopharyngeal carcinoma.Methods: Between March 1983 and November 2003, 82 patients were treated with curative intent and followed from 0.2 to 22 years (median, 5 years). Follow-up on living patients ranged from 2.8 to 22 years (median, 10.8 years). Thirty-two patients (39%) were treated once daily, 45 patients (55%) were treated with hyperfiractionation, and 5 patients (6%) were treated with the concomitant boost technique. Eight patients (10%) received intensity-modulated radiotherapy. Thirty-one patients (38%) received induction (17 patients) or concomitant (14 patients) chemotherapy. Fourteen patients (17%) underwent a planned neck dissection.Results: The 5-year outcomes after treatment were: local control, 78%; regional control, 90%; local-regional control, 76%; distant metastasis-free survival, 80%; cause-specific survival, 66%; and survival, 57%. The impact of T-stage, N-stage, overall stage, World Health Organization class, fractionation schedule, and adjuvant chemotherapy were evaluated in a multivariate analysis of various outcomes. Only N-stage and World Health Organization class impacted regional control.Conclusions: The likelihood of cure after RT is relatively high. Although the likelihood of cure diminished with increasing stage, none of the parameters evaluated significantly influenced outcomes aside from N-stage and WHO class.