Increased levels of the soluble adhesion molecule E‐selectin in essential hypertension
Increased levels of the soluble adhesion molecule E‐selectin in essential hypertension
复制标题
原发性高血压中可溶性粘附分子 E-选择素水平升高
DOI：
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发表时间：
1994
影响因子：
4.9
通讯作者：
Malcolm A. Waite
中科院分区：
文献类型：
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作者：
A. Blann;W. Tse;S. Maxwell;Malcolm A. Waite
目的探讨高血压患者血清可溶性E-选择素水平是否升高及其与血管性血友病因子水平的相关性。研究设计：连续45例未控制的高血压患者（血压>140/90 mmHg）和连续33例控制的高血压患者（血压<140/90 mmHg，即血压正常）进行了检查，并与40例血压正常的年龄和性别匹配的对照组进行了比较。方法采用酶联免疫吸附法测定静脉血中血管性血友病因子和可溶性E-选择素的水平。静脉穿刺前测量静息收缩压（SBP）和舒张压（DBP）。结果高血压患者血清可溶性E-选择素水平明显高于正常血压者和正常对照者。与对照组相比，高血压和正常血压患者的血管性血友病因子水平升高。在所有受试者的多因素分析中，血管性血友病因子水平与收缩压相关（P< 0.001），可溶性E-选择素水平与舒张压相关（P< 0.001），但血管性血友病因子和可溶性E-选择素水平不相关。内皮细胞指数水平与所用药物治疗类别或剂量之间无明显关系。结论高血压患者血清可溶性E-选择素水平升高并不提示内皮细胞损伤，但可能与内皮细胞活化有关。可溶性E-选择素释放的刺激可能不同于血管性血友病因子。
Objective To determine whether soluble E-selectin levels were raised in hypertension and whether such levels correlated with those of von Willebrand factor. Design Forty-five consecutive patients with uncontrolled hypertension (blood pressure >140/90 mmHg) and 33 consecutive patients with controlled hypertension (blood pressure <140/90 mmHg, i.e. normotension) were examined and compared with 40 normotensive age- and sex-matched controls. Methods Levels of von Willebrand factor and soluble E-selectin were measured by enzyme-linked immunosorbent assay in venous blood serum. Resting systolic (SBP) and diastolic (DBP) blood pressures were measured before venepuncture. Results Soluble E-selectin levels were raised in hypertension compared with controls and normotension. The levels of von Willebrand factor were raised in hypertension and normotension compared with controls. In multivariate analysis of all subjects, von Willebrand factor levels correlated with SBP (P< 0.001) and soluble E-selectin level correlated with DBP (P< 0.001), but levels of von Willebrand factor and soluble E-selectin did not correlate. There was no clear relationship between levels of either endothelial cell index or the class of drug therapy used or its dosage. Conclusions We suggest that raised levels of soluble E-selectin in hypertension do not indicate endothelial cell injury but may be related to endothelial cell activation. The stimulus for release of soluble E-selectin might be different from that for von Willebrand factor.