Synthesis and in vivo evaluation of bicyclic gababutins
Synthesis and in vivo evaluation of bicyclic gababutins
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DOI：
10.1016/j.bmcl.2009.11.118
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发表时间：
2010-01-15
影响因子：
2.7
通讯作者：
Williams, Sophie C.
中科院分区：
文献类型：
--
作者：
Blakemore, David C.;Bryans, Justin S.;Williams, Sophie C.
合成了一些加巴喷丁的双环五元环衍生物，鉴定了两个化合物，(-)-(11A)和(20A)，这两个化合物都具有很好的抗α(2)三角洲的效力，并且都是亲的。导致了神经病理性疼痛的体内模型。(C)2009爱思唯尔有限公司。保留所有权利。
Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (-)-(11A) and (20A) which both had an excellent level of potency against alpha(2)delta and were pro. led in an in vivo model of neuropathic pain. (C) 2009 Elsevier Ltd. All rights reserved.