Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry
Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry
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DOI：
10.1007/s00417-014-2667-6
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发表时间：
2014-08-01
影响因子：
2.7
通讯作者：
Hjortdal, Jesper
中科院分区：
文献类型：
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作者：
Pedersen, Iben Bach;Bak-Nielsen, Sashia;Hjortdal, Jesper
采用基于scheimpflug的动态眼压仪（Corvis ST）和非接触式差分眼压仪（Ocular Response Analyzer， ORA）评估LASIK、ReLEx flex和无瓣手术后角膜的生物力学特性。在奥尔胡斯大学医院治疗高度近视（-10.5至-5.5屈光度，球面等效屈光度）超过一年的患者被纳入研究。治疗包括LASIK（35只眼睛）、ReLEx flex（31只眼睛）和ReLEx smile（29只眼睛）。对照组包括31只健康的眼睛。采用ORA法测定角膜代偿性IOP （IOPcc）、角膜迟滞（CH）、角膜阻力因子（CRF）。在空气脉冲期间用Corvis ST记录角膜压平和变形。多元线性回归分析显示，与健康对照组相比，所有角膜屈光手术后CH和CRF均显著降低（p < 0.05）。角膜屈光组间CH或CRF无显著差异。两组间Corvis ST在最大凹度半径（HC半径）、第一次压平时间（A1时间）、第二次压平时间（A2时间）和最大凹度挠度长度（HC挠度长度）上均无差异。LASIK组达到最高凹的时间明显短于ReLEx smile组（HC time, p = 0.01）。角膜屈光组的A1偏转长度明显短于正常对照组（p < 0.05）。角膜移植手术改变了角膜的生物力学特性，包括角膜迟滞和角膜抵抗因子。通过Corvis ST和ORA评估，基于皮瓣的LASIK和ReLEx flex和无皮瓣的ReLEx smile在角膜生物力学方面的降低相似。
To evaluate corneal biomechanical properties after LASIK, ReLEx flex, and the flap-free procedure ReLEx smile by Scheimpflug-based dynamic tonometry (Corvis ST) and non-contact differential tonometry (Ocular Response Analyzer, ORA).Patients treated for high myopia (-10.5 to -5.5 diopters, spherical equivalent refraction) more than one year previously at Aarhus University Hospital were included. Treatments comprised LASIK (35 eyes), ReLEx flex (31 eyes), and ReLEx smile (29 eyes). A control group included 31 healthy eyes. Cornea-compensated IOP (IOPcc), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured with ORA. Corneal applanation and deformation were registered with Corvis ST during an air-pulse.Multiple linear regression analysis showed that CH and CRF were significantly lower after all keratorefractive procedures compared to healthy controls (p < 0.05). No significant differences were observed in CH or CRF between the keratorefractive groups. Corvis ST showed no differences in radius at highest concavity (HC radius), time until first applanation (A1 Time), time until second applanation (A2 Time), and deflection length at highest concavity (HC deflection length) between groups. LASIK treated eyes had significantly shorter time until highest concavity than eyes treated with ReLEx smile (HC Time, p = 0.01). The A1 deflection length was significantly shorter in the keratorefractive groups compared to the healthy controls (p < 0.05).Keratorefrative procedures alter the corneal biomechanical properties with regard to corneal hysteresis and corneal resistant factor. The flap-based LASIK and ReLEx flex and the flap-free ReLEx smile result in similar reduction in corneal biomechanics when evaluated by Corvis ST and ORA.