Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects
Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects
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DOI：
10.1093/ajcn/87.3.577
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发表时间：
2008-03-01
影响因子：
7.1
通讯作者：
George, Peter M.
中科院分区：
文献类型：
--
作者：
Atkinson, Wendy;Elmslie, Jane;George, Peter M.
Background: Betaine comes from the diet and from choline, and it is associated with vascular disease in some patient groups. Betaine supplementation lowers plasma total homocysteine.Objective: We compared the acute effects of dietary and supplementary betaine and choline on plasma betaine and homocysteine under standard conditions and after a methionine load.Design: In a randomized crossover study, 8 healthy men (19-40 y) consumed a betaine supplement (approximate to 500 mg), high-betaine meal (approximate to 517 mg), choline supplement (500 mg), high-choline meal (approximate to 564 mg), high-betaine and -choline meal (approximate to 517 mg betaine, approximate to 622 mg choline), or a low-betaine and -choline control meal under standard conditions or postmethionine load. Plasma betaine, dimethylglycine, and homocysteine concentrations were measured hourly for 8 h and at 24 h after treatment.Results: Dietary and supplementary betaine raised plasma betaine concentrations relative to control (P < 0.001) under standard conditions. This was not associated with raised plasma dimethylglycine concentration, and no significant betaine appeared in the urine. A small increase in dimethylglycine excretion was observed when either betaine or choline was supplied (P = 0.011 and < 0.001). Small decreases in plasma homocysteine 6 h after ingestion under standard conditions (P
