Internally Recurring Hippocampal Sequences as a Population Template of Spatiotemporal Information.
Internally Recurring Hippocampal Sequences as a Population Template of Spatiotemporal Information.
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DOI：
10.1016/j.neuron.2015.09.052
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发表时间：
2015-10-21
期刊：
影响因子：
16.2
通讯作者：
Cossart R
中科院分区：
文献类型：
--
作者：
Villette V;Malvache A;Tressard T;Dupuy N;Cossart R
海马体对于时空认知是必不可少的。神经元激活序列为这一基本功能提供了底物。在行为时间尺度上，这些序列已经被证明要么在连续的外部地标存在的情况下发生，要么通过情节记忆任务中的内部机制发生。在这两种情况下，活动都受到任务组织和所探索环境的大小的外部限制。因此，在没有任何外部记忆需求或时空边界的情况下，海马区的活动是否能够自组织到默认模式仍然是未知的。在这里，我们表明，在自我运动提示的存在下，整合距离的种群代码自然以重复序列的形式出现在海马体中。由于行程距离分布为这些序列跨度的整数倍，因此这些内部动态钳位自发行程。因此，当外部地标减少时，这些序列可以指导导航。在没有外部线索的情况下，海马体动力学自发地显示重复序列，重复序列跨越固定的行程距离，序列是塑造小鼠行为序列的内部认知模板，显示出内部硬连线的功能结构，海马体支持时空认知。维莱特和马尔瓦赫等人在清醒小鼠的海马区使用钙成像。研究表明，在自我运动的影响下，神经元激活的刻板印象序列，整合了行为的时空成分，在没有任何外部驱动的情况下自发重现。
The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic memory task. In both cases, activity is externally constrained by the organization of the task and by the size of the environment explored. Therefore, it remains unknown whether hippocampal activity can self-organize into a default mode in the absence of any external memory demand or spatiotemporal boundary. Here we show that, in the presence of self-motion cues, a population code integrating distance naturally emerges in the hippocampus in the form of recurring sequences. These internal dynamics clamp spontaneous travel since run distance distributes into integer multiples of the span of these sequences. These sequences may thus guide navigation when external landmarks are reduced. Without external cues, hippocampal dynamics spontaneously display recurring sequences Recurring sequences span across a fixed traveled distance Sequences are an internal cognitive template that shapes mouse behavior Sequences display an internally hardwired functional structure The hippocampus supports spatiotemporal cognition. Using calcium imaging in the hippocampus of awake mice, Villette and Malvache et al. show that stereotyped sequences of neuronal activation, integrating spatiotemporal components of behavior, spontaneously recur, without any external drive, under the influence of self-motion.