Incidence and management of infections in patients with acute leukemia following chemotherapy in general wards.
Incidence and management of infections in patients with acute leukemia following chemotherapy in general wards.
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DOI：
10.3332/ecancer.2013.310
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发表时间：
2013
影响因子：
1.8
通讯作者：
Godnaik C
中科院分区：
文献类型：
--
作者：
Biswal S;Godnaik C
我们假设，在普通病房治疗急性白血病患者，适当的卫生和卫生习惯，将导致最低限度的资源利用相比，相应的患者接受ICU支持。在本研究中，接受诱导化疗的急性白血病患者留在普通病房，观察中性粒细胞减少症的发生率、导致的贫血性发热、病原体以及经验性抗菌治疗方案对此类感染结局的影响。预防性抗真菌治疗和复方新诺明治疗改善了感染的结局。对贫血性发热和感染的治疗必须根据危险因素进行调整，并应包括早期经验性抗真菌治疗。据观察，这类病人在普通病房的治疗可以得到有效的管理，并有最佳利用资源和在病人友好的环境中的额外优势，病人的费用也是合理的。
We hypothesise that treating patients with acute leukaemia in general wards, with proper hygienic and sanitary practices, would result in the minimum utilisation of resources as compared with the corresponding patients receiving ICU support. For this study, the acute leukaemia patients on induction chemotherapy were kept in general wards and observed for the incidence of neutropenia, resultant neutropenic febriles, the causative organism, and the effect of empirical antimicrobial treatment protocol on the outcome of such infections. Prophylactic anti-fungal therapy and cotrimoxazole therapy improved the outcome of infections. The therapy of neutropenic fever and infections must be adapted according to the risk factors and should include early empiric antifungal therapy. It was observed that the treatment of such patients in general wards could be managed effectively, with the added advantage of optimum utilisation of resources and in a patient-friendly environment, at a reasonable cost to the patients.