Validation of the iATL-PI prognostic index in therapeutic decision-making for patients with smoldering and chronic ATL: a multicenter study
Validation of the iATL-PI prognostic index in therapeutic decision-making for patients with smoldering and chronic ATL: a multicenter study
复制标题
冒烟型和慢性 ATL 患者治疗决策中 iATL-PI 预后指数的验证：一项多中心研究
DOI：
10.1007/s12185-022-03473-y
复制
发表时间：
2022
影响因子：
2.1
通讯作者：
Tsukasaki Kun
中科院分区：
文献类型：
--
作者：
Imaizumi Yoshitaka;Iwanaga Masako;Nosaka Kisato;Ishitsuka Kenji;Ishizawa Kenichi;Ito Shigeki;Amano Masahiro;Ishida Takashi;Uike Naokuni;Utsunomiya Atae;Ohshima Koichi;Tanaka Junji;Tokura Yoshiki;Tobinai Kensei;Watanabe Toshiki;Uchimaru Kaoru;Tsukasaki Kun
成人T细胞白血病-淋巴瘤（ATL）临床上是异质性的，分为四种亚型：急性、淋巴瘤、慢性和阴燃型。最近，一个新的预后指标的基础上的可溶性白细胞介素-2受体的价值，表示为“iATL-PI”，已被提出的郁积和慢性ATL患者。为了评估iATL-PI的有效性，我们重新分析了2010年至2011年期间诊断的176例郁积或慢性ATL患者（76例郁积，100例慢性）的既往发表数据，以及2016年至2017年期间后续预后随访研究的数据。在ATL诊断时，低风险、中等风险和高风险iATL-PI组的比例对于阴燃ATL分别为44. 7%、48. 7%和5%;对于有利的慢性ATL分别为6. 3%、71. 9%和21. 9%;对于不利的慢性ATL分别为5. 9%、27. 9%和66. 2%。根据三个iATL-PI组，对阴燃或慢性ATL患者的生存率进行了显著分层。iATL-PI低风险组中大多数患有不利慢性ATL的患者具有惰性临床病程。我们的研究结果表明，iATL可能成为一个有用的工具来预测阴燃和慢性ATL，这有不同的临床过程的预后。
Adult T cell leukemia-lymphoma (ATL) is clinically heterogeneous and is classified into four subtypes: acute, lymphoma, chronic, and smoldering. Recently, a new prognostic index based on the value of soluble interleukin-2 receptor, denoted the “iATL-PI,” has been proposed for patients with smoldering and chronic ATL. To evaluate the effectiveness of the iATL-PI, we re-analyzed our previously published data on 176 patients with smoldering or chronic ATL (76 smoldering, 100 chronic) diagnosed between 2010 and 2011, as well data from the subsequent follow-up study on prognosis between 2016 and 2017. The proportions for the low-, intermediate-, and high-risk iATL-PI groups at the time of ATL diagnosis were 44.7%, 48.7%, and 5% for smoldering ATL; 6.3%, 71.9%, and 21.9% for favorable chronic ATL; and 5.9%, 27.9%, and 66.2% for unfavorable chronic ATL, respectively. The survival of patients with smoldering or chronic ATL as a whole was significantly stratified according to the three iATL-PI groups. Most patients with unfavorable chronic ATL in the low iATL-PI risk group had indolent clinical courses. Our results showed that iATL may become a useful tool to predict the prognosis of smoldering and chronic ATL, which have diverse clinical courses.
Ohshima, K.：“bcl-2 益处和 B 细胞淋巴瘤的预后”(1991)。
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Kataoka, Keisuke;Shiraishi, Yuichi;Ogawa, Seishi
通讯作者：
Ogawa, Seishi
影响因子：
6.5
作者：
SHIMOYAMA, M
通讯作者：
SHIMOYAMA, M