Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications
Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications
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DOI：
10.1021/ja073790m
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发表时间：
2007-11-28
影响因子：
15
通讯作者：
Bawendi, Moungi
中科院分区：
文献类型：
--
作者：
Liu, Wenhao;Choi, Hak Soo;Bawendi, Moungi
我们已经开发了一种多功能的纳米粒子结构，使用紧凑的半胱氨酸涂层的CdSe（ZnCdS）的核心（壳）量子点（QD-Cys），是生物相容的，非常紧凑，高荧光，易于功能化。QD-Cys的小流体动力学直径（类似于6 nm）允许这些纳米颗粒在大鼠模型中的肾清除。此外，直接缀合至QD-Cys的能力开启了用于体内靶向成像的官能化纳米晶体的可能性，其中小的靶向分子可以附加至QD-Cys，并且未结合的QD可以被快速清除以实现高信噪比并降低背景毒性。
We have developed a versatile nanoparticle construct using a compact cysteine coating on a CdSe(ZnCdS) core(shell) nanocrystal (QD-Cys) that is biologically compatible, exceptionally compact, highly fluorescent, and easily functionalized. The small hydrodynamic diameter of QD-Cys (similar to 6 nm) allows for renal clearance of these nanoparticles in rat models. Moreover, the ability to directly conjugate to QD-Cys opens up the possibility of functionalized nanocrystals for in vivo targeted imaging, in which small targeting molecules can be appended to QD-Cys, and unbound QDs can be rapidly cleared to achieve high signal/noise ratios and to reduce background toxicity.