Elevated plasma eotaxin levels in patients with acute asthma
Elevated plasma eotaxin levels in patients with acute asthma
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DOI：
10.1016/s0091-6749(99)70288-5
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发表时间：
1999-10-01
影响因子：
14.2
通讯作者：
Hanrahan, JP
中科院分区：
文献类型：
--
作者：
Lilly, CM;Woodruff, PG;Hanrahan, JP
背景资料：嗜酸性粒细胞趋化因子的趋化和活化作用以及嗜酸性粒细胞与哮喘的已知关联表明，嗜酸性粒细胞趋化因子的表达在哮喘急性发作期间增加。目的：我们试图确定急性哮喘急诊治疗患者的血浆嗜酸性粒细胞趋化因子水平是否升高，并将嗜酸性粒细胞趋化因子水平与疾病活动性和对治疗的反应相关联。在36名接受紧急哮喘治疗的患者和133名年龄、性别和种族匹配的稳定型哮喘受试者中进行了血浆嗜酸性粒细胞趋化因子水平的病例对照研究，结果：36例有急性哮喘症状和气流阻塞的患者血浆嗜酸性粒细胞趋化因子水平显著升高（520 pg/mL [250，1100 pg/mL];几何平均值[-1 SD，+1 SD]）（350 pg/mL [190，620 pg/ml]; P = 0.0008），在紧急哮喘发作的患者中，那些对哮喘治疗有反应，呼气峰流速增加至少等于其预测正常值的20%的患者，其嗜酸性粒细胞趋化因子水平低于那些没有反应的患者。（410 pg/mL [210，800 pg/mL]和660 pg/mL [300，1480 pg/mL]; P = 0.01）.结论：这些发现暗示嗜酸性粒细胞趋化因子在急性哮喘中机制性地参与或作为CCR 3受体配体系统活性的生物标志物系列，其在功能上与哮喘相关。
Background: The eosinophil chemotactic and activating effects of eotaxin and the known association of eosinophils with asthma suggest that eotaxin expression is increased during asthma exacerbations.Objective: We sought to determine whether plasma eotaxin levels are elevated in patients presenting for emergency treatment of acute asthma and to correlate eotaxin levels with disease activity and responses to treatment.Methods: A case-control study of plasma eotaxin levels was performed in the 36 patients who presented for emergency asthma treatment and 133 age-, sex-, and ethnicity-matched subjects with stable asthma,Results: Plasma eotaxin levels were significantly higher in 36 patients with acute asthma symptoms and airflow obstruction (520 pg/mL [250, 1100 pg/mL]; geometric mean [-1 SD, +1 SD]) than in 133 subjects with stable asthma (350 pg/mL [190, 620 pg/ml]; P = .0008), Among the patients with emergency asthma flares, those who responded to asthma treatment with an increase in peak expiratory flow rate by an amount equal to at least 20% of their predicted normal value had lower eotaxin levels than those who did not (410 pg/mL [210, 800 pg/mL] and 660 pg/mL [300, 1480 pg/mL], respectively; P = .01).Conclusion: These findings imply that eotaxin either is mechanistically involved in acute asthma or series as a biomarker for activity of the CCR3 receptor ligand system, which is functionally linked to asthma.