Lymphatic invasion according to D2‐40 immunostaining is a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus
Lymphatic invasion according to D2‐40 immunostaining is a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus
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D2-40 免疫染色显示的淋巴侵袭是子宫体子宫内膜样腺癌淋巴结转移的预测因子
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
S. Takeda
中科院分区：
文献类型：
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作者：
Yasuka Miyakuni;Toshiharu Matsumoto;A. Arakawa;H. Sonoue;C. Suzuki;S. Takeda
在子宫体类腺癌中，淋巴结转移与预后有关。D2 - 40免疫染色最近已被用于检测淋巴管浸润，但D2 - 40免疫染色用于子宫体类腺瘤样腺癌的研究尚未发表。因此，将D2 - 40免疫染色检测淋巴管浸润和HE染色检测淋巴管浸润作为子宫体类腺癌淋巴结转移的预测指标。共104例子宫体浸润性类腺癌，其中肿瘤位于子宫内，使用D2 - 40进行免疫组化检查。在20例病例中，根据D2 - 40免疫染色存在淋巴管浸润，并且D2 - 40免疫染色可很好地检测到淋巴管浸润。淋巴结转移11例。D2 - 40免疫染色的淋巴管浸润和HE染色的淋巴管浸润与淋巴结转移具有统计学相关性，但在当前和既往研究中，D2 - 40免疫染色的淋巴管浸润评估比HE染色检测淋巴管浸润更准确，用于预测淋巴结转移。总之，D2 - 40免疫染色显示的淋巴管浸润作为子宫体类腺瘤淋巴结转移的预测因子非常有用。
In endometrioid adenocarcinoma of the uterine corpus, nodal metastasis is related to prognosis. D2‐40 immunostaining has recently been used to detect lymphatic invasion, but a study of D2‐40 immunostaining for endometrioid adenocarcinoma of the uterine corpus has not been published. Therefore, as a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus, the detection of lymphatic invasion on D2‐40 immunostaining and lymphovascular invasion on HE stain was compared. A total of 104 cases of invasive endometrioid adenocarcinoma of the uterine corpus, in which the tumor was located in the uterus, were examined on immunohistochemistry using D2‐40. In 20 cases there was lymphatic invasion according to D2‐40 immunostaining, and the lymphatic invasion was well detected on D2‐40 immunostaining. Nodal metastasis was present in 11 cases. Both lymphatic invasion on D2‐40 immunostaining and lymphovascular invasion on HE stain were statistically correlated with nodal metastasis, but the evaluation of lymphatic invasion on D2‐40 immunostaining was more accurate than detection of lymphovascular invasion using HE stain, in the current and previous studies, for the prediction of nodal metastasis. In conclusion, lymphatic invasion demonstrated on D2‐40 immunostaining is very useful as a predictor for nodal metastasis in endometrioid adenocarcinoma of uterine corpus.