Metabolism of subcutaneous administered indium arsenide in the hamster.
Metabolism of subcutaneous administered indium arsenide in the hamster.
复制标题
仓鼠皮下注射砷化铟的代谢。
DOI：
10.1016/0041-008x(92)90145-i
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发表时间：
1992
影响因子：
3.8
通讯作者：
Fowler,BA
中科院分区：
文献类型：
--
作者：
Yamauchi,H;Takahashi,K;Yamamura,Y;Fowler,BA
砷化铟（InAs）在体内部分解离形成无机砷和铟，并排泄到尿液和粪便中。随着时间的推移，InAs溶解缓慢，并在注射部位沉积。本研究结果表明，仓鼠尿液中砷的主要代谢产物是二甲基化砷（DMA）。无机砷和DMA在毛皮中积累，而铟在该基质中的浓度很低。尿液和粪便是排出体内的主要途径。对组织中砷的分析显示其浓度在十亿分之一范围内。这些研究结果表明，InAs在体内解离，同时释放铟和砷部分到靶组织。
Indium arsenide (InAs) is partially dissociated in vivo to form inorganic arsenic and indium and excreted into the urine and feces. InAs dissolves slowly over time with deposits at the site of injection. Results of this study demonstrated that the principal metabolite of arsenic in the urine of hamsters was dimethylated arsenic (DMA). Inorganic arsenic and DMA accumulated in the fur, but the concentrations of indium were very low in this matrix. Urine and feces were the principal routes of elimination from the body. Analysis of tissues for arsenic demonstrated as concentrations in the parts per billion range. Results of these studies indicate that InAs is dissociated in vivo with release of both the indium and arsenic moieties to target tissues.