Distribution of GICA in normal gastrointestinal and endocervical mucosae and in mucinous ovarian cysts using antibody NS 19-9.
Distribution of GICA in normal gastrointestinal and endocervical mucosae and in mucinous ovarian cysts using antibody NS 19-9.
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使用抗体 NS 19-9 观察 GICA 在正常胃肠道和宫颈内膜以及粘液性卵巢囊肿中的分布。
DOI：
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发表时间：
1986
影响因子：
3.5
通讯作者：
P. Burtin
中科院分区：
文献类型：
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作者：
J. Bara;E. H. Zabaleta;R. Mollicone;M. Nap;P. Burtin
通过使用抗体19-9的免疫过氧化物酶法，我们证明了在Le（a+B-）和Le（a-B+）患者中，在正常胃肠道和宫颈内膜粘膜以及纯宫颈内膜型良性粘液性卵巢囊肿中存在胃肠道癌相关抗原（GICA）。然而，GICA在Le（a+B-）患者中的定量表达高于Le（a-B+）患者。GICA多见于食管腺管、维尔松管、回结肠交界处绒毛杯状细胞、宫颈粘膜的粘液柱状细胞或卵巢粘液性肿瘤上皮。在胃肠道的其他区域，GICA有时见于食管腺的粘液细胞、胃粘膜颈细胞附近、小肠绒毛上部的杯状细胞和结肠Lieberkühn腺，尤其是细胞成熟区。因此，GICA似乎是胃肠道和宫颈内粘膜的正常组成部分。
Through the immunoperoxidase method using antibody 19-9, we demonstrated the presence of gastrointestinal cancer-associated antigen (GICA) in normal gastrointestinal and endocervical mucosae and in benign mucinous ovarian cysts of pure endocervical type in Le(a+b-) and Le(a-b+) patients exclusively. However, GICA was more quantitatively expressed in Le(a+b-) than in Le(a-b+) patients. GICA was always encountered in the ducts of esophageal glands, Wirsung's ducts, goblet cells of villosities near the ileo-colonic junction, and the mucus columnar cells of the endocervical mucosae or ovarian mucinous tumor epithelium. In other areas of the gastrointestinal tract, GICA was sometimes found in the mucus cells of esophageal glands, near the neck cells of gastric mucosae, in goblet cells of the upper part of the small intestinal villosities, and in colonic Lieberkühn glands, especially in the cell maturation compartment. GICA therefore appears to be a normal component of gastrointestinal and endocervical mucosae.