The effect of chronic adrenergic receptor blockade on plasma renin activity in man.
The effect of chronic adrenergic receptor blockade on plasma renin activity in man.
复制标题
慢性肾上腺素能受体阻断对人血浆肾素活性的影响。
DOI：
10.1210/jcem-34-2-386
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
R. G. Mcallister
中科院分区：
文献类型：
--
作者：
A. Michelakis;R. G. Mcallister
The response of plasma renin activity (PRA) to the stimuli of upright posture and sodium deprivation was determined in three normal adults and in ten hypertensive patients before and after chronic alpha-adrenergic receptor blockade with phenoxybenzamine and chronic beta-blockade with propranolol. Alpha-receptor blockade produced little effect on supine or upright PRA values; beta-receptor blockade, however, consistently and significantly suppressed PRA in both the supine and standing positions. Dose-response studies suggest that the maximal suppression of PRA attainable after oral propranolol administration occurs at peak plasma levels of about 30–50 ng/ml. Beta-adrenergic receptors appear to constitute that part of the sympathetic nervous system which mediates a significant portion of the renin release mechanism. Pharmacologic interference with renin secretion by beta-adrenergic receptor blockade is easily achieved in both normal and hypertensive subjects. The suppression of supine and upright PRA with b...
