[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine
[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine
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DOI：
10.1002/anie.200907047
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Roach, Peter L.
中科院分区：
文献类型：
--
作者：
Driesener, Rebecca C.;Challand, Martin R.;Roach, Peter L.
“化学方程式呈现”你的毒药是什么？氢化酶催化由两个电子和两个质子可逆地形成二氢。[FeFe]-氢化酶活性位点辅因子（H簇）的成熟需要三种基因产物，HydE、HydF和HydG。氰化物已被表征为S-腺苷甲硫氨酸依赖性酶HydC切割酪氨酸的产物之一，阐明了其在H-簇生物合成中的作用。© 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
" Chemical Equation Presented" What's your poison? Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]-hydrogenase active-site cofactor (H cluster) requires three gene products, HydE, HydF, and HydG. Cyanide has been characterized as one of the products of tyrosine cleavage by the S-adenosylmethionine-dependent enzyme HydC, clarifying its role in H-cluster biosynthesis. DOA= deoxyadenosine.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA.