EXPRESSION OF 2 VARIANT SURFACE GLYCOPROTEINS ON INDIVIDUAL AFRICAN TRYPANOSOMES DURING ANTIGEN SWITCHING
EXPRESSION OF 2 VARIANT SURFACE GLYCOPROTEINS ON INDIVIDUAL AFRICAN TRYPANOSOMES DURING ANTIGEN SWITCHING
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DOI：
10.1126/science.3892689
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
SCHOENBECHLER, MJ
中科院分区：
文献类型：
--
作者：
ESSER, KM;SCHOENBECHLER, MJ
Individual Trypanosoma brucei rhodesiense organisms were observed in the process of switching variant surface glycoproteins (VSG). During this switch, trypanosomes simultaneously expressed both pre- and postswitch VSG uniformly over their surface as detected with monoclonal antibodies. Analysis of this switching event showed that trypanosomes expressing any one of 3 distinct preswitch VSG could switch to expression of from 1-3 different postswitch VSG. Up to 2.7% of the trypanosome population was in the process of switching at one time.
