Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease
Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease
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DOI：
10.1016/j.jacl.2018.08.006
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发表时间：
2018-12-01
影响因子：
4.4
通讯作者：
Yamagishi, Masakazu
中科院分区：
文献类型：
--
作者：
Tada, Hayato;Kawashiri, Masa-aki;Yamagishi, Masakazu
背景技术背景：严重家族性高胆固醇血症（FH）的遗传背景尚未确定。目的：我们测试了与低密度脂蛋白（LDL）改变相关的常染色体隐性遗传病的遗传变异是否影响高LDL胆固醇患者的LDL胆固醇水平和冠状动脉疾病的几率。方法：我们招募了500名LDL胆固醇水平升高的个体（受试者为>= 180 mg/dL或>= 140 mg/dL
BACKGROUND: The genetic background of severe familial hypercholesterolemia (FH) has yet to be determined.OBJECTIVE: We tested if genetic variants associated with low-density lipoprotein (LDL)-altering autosomal recessive diseases influenced LDL cholesterol levels and the odds for coronary artery disease in patients with high LDL cholesterol.METHODS: We recruited 500 individuals with elevated LDL cholesterol levels (>= 180 mg/dL or >= 140 mg/dL for subjects