Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent
Molecular mechanisms and biomedical applications of glucosamine as a potential multifunctional therapeutic agent
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DOI：
10.1016/j.lfs.2016.03.028
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发表时间：
2016-05-01
期刊：
影响因子：
6.1
通讯作者：
Jamialahmadi, Khadijeh
中科院分区：
文献类型：
--
作者：
Dalirfardouei, Razieh;Karimi, Gholamreza;Jamialahmadi, Khadijeh
氨基葡萄糖及其乙酰化衍生物 N-乙酰氨基葡萄糖是人体内天然存在的氨基糖。它们是糖蛋白、蛋白聚糖和糖胺聚糖的重要组成部分。科学研究支持葡萄糖胺具有缓解骨关节炎症状的有益药理作用。由于其抗氧化和抗炎活性，氨基葡萄糖也可以作为预防和/或治疗一些其他疾病的有前途的候选者。其大部分功能是通过调节炎症反应来发挥的，尤其是通过核因子-κ B (NF-κ B)，它可以控制炎症细胞因子的产生和细胞存活。在这篇综述中，我们对氨基葡萄糖的其他新治疗应用进行了简要更新，包括治疗心血管疾病、神经缺陷、皮肤病、癌症以及这些用途的分子机制原理。本文还将研究氨基葡萄糖对人体的安全性和不良影响。 (c) 2016 Elsevier Inc. 保留所有权利。
Glucosamine and its acetylated derivative, N-acetyl glucosamine, are naturally occurring amino sugars found in human body. They are important components of glycoproteins, proteoglycans and glycosaminoglycans. Scientific studies have supported that glucosamine has the beneficial pharmacological effects to relieve osteoarthritis symptoms. Glucosamine can also be as a promising candidate for the prevention and/or treatment of some other diseases due to its anti-oxidant and anti-inflammatory activities. Most of its function is exerted by modulation of inflammatory responses especially through Nuclear Factor-kappa B (NF-kappa B) that can control inflammatory cytokine production and cell survival. In this review, we present a concise update on additional new therapeutic applications of glucosamine including treatment of cardiovascular disease, neurological deficits, skin disorders, cancer and the molecular mechanistic rationale for these uses. This article will also examine safety profile and adverse effects of glucosamine in human. (c) 2016 Elsevier Inc. All rights reserved.