Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies
Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies
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DOI：
10.1093/ije/dyg094
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发表时间：
2003-06-01
影响因子：
7.7
通讯作者：
Hoover, RN
中科院分区：
文献类型：
--
作者：
Troisi, R;Potischman, N;Hoover, RN
背景流行病学研究表明，先兆子痫妊娠的成年女儿患乳腺癌的风险显著降低，母亲的风险也有适度的降低。妊娠激素浓度的变化，特别是在子宫内暴露于雌激素的情况下，被认为是调节这种联系的媒介。方法对86例先兆子痫和86例无并发症的单胎妊娠患者入院分娩和分娩时收集的孕妇血清中的妊娠激素水平进行了测定，这些孕妇的孕期长度、母亲年龄、产次和分娩类型都匹配。在一项配对分析中，不论是在分娩开始之前还是之后采集血液，先兆子痫孕妇的血清未结合雌二醇、雌酮和雌三醇浓度并未降低。然而，与对照组相比，子痫前期组血清未结合雄烯二酮(506.3对316.0 ng/dl；P=0.0007)和睾酮浓度(214.5对141.9 ng/dl；P=0.004)显著升高，而脱氢表雄酮(DHEA)和脱氢表雄酮硫酸盐(DHEA)则无显著差异。结论这些数据不支持子痫前期母亲和子代的癌症风险是通过暴露于较低的母血雌激素浓度来解释的假设，但增加了雄激素发挥作用的可能性。
Background Epidemiological studies show a substantially reduced risk of breast cancer in adult daughters of preeclamptic pregnancies, and modest risk reductions have been demonstrated for mothers also. Alterations in pregnancy hormone concentrations, particularly lower in utero exposure to oestrogen, are hypothesized to mediate this association.Methods Pregnancy hormone concentrations were measured in maternal sera collected at hospital admission for labour and delivery from 86 preeclamptic and 86 uncomplicated, singleton pregnancies matched on length of gestation, maternal age, parity, and type of delivery.Results Case and control pregnancies were similar in several maternal and pregnancy factors. Serum unconjugated oestradiol, oestrone, and oestriol concentrations were not lower in preeclamptic pregnancies in a matched analysis with adjustment for race and whether blood was collected before or after labour commenced. Serum unconjugated androstenedione (506.3 versus 316.0 ng/dl; P = 0.0007) and testosterone concentrations (214.5 versus 141.9 ng/dl; P = 0.004), however, were significantly higher in preeclamptic compared with control pregnancies, whereas dehydroepiandrosterone (DHEA) and DHEA sulphate did not differ.Conclusions These data do not support the hypothesis that cancer risk in mothers and offspring of preeclamptic pregnancies is explained by exposure to lower maternal blood oestrogen concentrations, but raise the possibility that androgens play a role.