Effect of low‐dose epinephrine infusion on hemodynamics after selective and nonselective β‐blockade in hypertension
Effect of low‐dose epinephrine infusion on hemodynamics after selective and nonselective β‐blockade in hypertension
复制标题
小剂量肾上腺素输注对高血压选择性和非选择性β受体阻滞后血流动力学的影响
DOI：
10.1038/clpt.1982.96
复制
发表时间：
1982
影响因子：
6.7
通讯作者：
A. Laar
中科院分区：
文献类型：
--
作者：
H. Houben;T. Thien;A. Laar
我们研究了低剂量肾上腺素对5例接受普萘洛尔和美托洛尔长期治疗的高血压患者的血流动力学影响。以0.5、1.0、2.0和4.0 μg/min的速率输注肾上腺素。在普萘洛尔治疗期间，肾上腺素在所有速率下均诱导显著的升压效应。收缩压和舒张压显著升高，心率下降。在美托洛尔治疗期间，血压和心率仅轻微升高。在普萘洛尔治疗期间，肾上腺素可降低前臂血流量。计算的前臂血管阻力表现出相反的效果。我们的结论是，输注小剂量肾上腺素导致普萘洛尔和美托洛尔治疗患者的反应存在显著差异，这可能与选择用于治疗高血压的β受体阻滞剂有关。
We studied hemodynamic effects of low doses of epinephrine in five hypertensive patients receiving long‐term treatment with propranolol and metoprolol. Epinephrine was infused at graded rates of 0.5, 1.0, 2.0, and 4.0 µg/min. During propranolol treatment epinephrine induced a marked pressor effect at all rates. There was a considerable rise in systolic as well as in diastolic blood pressure and heart rate fell. During metoprolol treatment there was only a slight rise in blood pressure and heart rate rose. Forearm blood flow was decreased by epinephrine during propranolol. Calculated forearm vascular resistance showed opposite effects. We conclude that infusion of small doses of epinephrine results in a marked difference in reaction in propranolol‐ and metoprolol‐treated patients and that this may have relevance in the choice of beta blocker to be used in the treatment of hypertension.