Construction of a deformable spatiotemporal MRI atlas of the fetal brain: evaluation of similarity metrics and deformation models.
Construction of a deformable spatiotemporal MRI atlas of the fetal brain: evaluation of similarity metrics and deformation models.
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DOI：
10.1007/978-3-319-10470-6_37
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发表时间：
2014
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影响因子：
--
通讯作者：
Warfield, Simon K
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文献类型：
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作者：
Gholipour, Ali;Limperopoulos, Catherine;Clancy, Sean;Clouchoux, Cedric;Akhondi-Asl, Alireza;Estroff, Judy A;Warfield, Simon K
开发和确定胎儿大脑MRI分析的最佳方法至关重要，因为我们预计未来几年将爆发对GroupWise和早期大脑发育的纵向分析的研究。为了解决这一关键需求，在本文中，我们开发了一个数学框架，用于构建无偏可变形的胎脑MRI时空图谱，并在相似性度量和变形模型方面将其与其他配置进行比较。我们的贡献有两方面：第一，我们提出了一种新的构建胎儿大脑时空图谱的方法，该方法显示了捕捉受试者之间解剖差异的高能力；第二，在我们的图谱构建框架内，我们评估和比较了一组可信的受试者间胎儿大脑MRI配准的配置，并确定了最准确的方法，这可能会在人群图谱构建、基于图谱的分割和群体分析中产生最准确的结果。我们的评估结果表明，具有互相关相似性度量的对称微分同胚形变配准比其他配置在这一应用中具有更好的性能，并产生了可用于胎儿大脑MRI分析的锐利的无偏图谱。
The development and identification of best methods in fetal brain MRI analysis is crucial as we expect an outburst of studies on groupwise and longitudinal analysis of early brain development in the upcoming years. To address this critical need, in this paper, we have developed a mathematical framework for the construction of an unbiased deformable spatiotemporal atlas of the fetal brain MRI and compared it to alternative configurations in terms of similarity metrics and deformation models. Our contributions are twofold: first we suggest a novel approach to fetal brain spatiotemporal atlas construction that shows high capability in capturing anatomic variation between subjects; and second, within our atlas construction framework we evaluate and compare a set of plausible configurations for inter-subject fetal brain MRI registration and identify the most accurate approach that can potentially lead to most accurate results in population atlas construction, atlas-based segmentation, and group analysis. Our evaluation results indicate that symmetric diffeomorphic deformable registration with cross correlation similarity metric outperforms other configurations in this application and results in sharp unbiased atlases that can be used in fetal brain MRI analysis.