Remarkable vessel enlargement within lung consolidation in COVID-19 compared to AH1N1 pneumonia: A retrospective study in Italy.
Remarkable vessel enlargement within lung consolidation in COVID-19 compared to AH1N1 pneumonia: A retrospective study in Italy.
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DOI：
10.1016/j.heliyon.2021.e07112
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发表时间：
2021-05
期刊：
影响因子：
4
通讯作者：
Study Investigators
中科院分区：
文献类型：
--
作者：
Bianco A;Valente T;Perrotta F;Stellato E;Brunese L;Wood BJ;Carrafiello G;Parrella R;Study Investigators
与甲型流感病毒H1N1（AH 1 N1）相比，研究COVID-19肺炎的早期CT表现，重点关注实变或毛玻璃样阴影（GGO）区域内的血管增大。对50名COVID-19肺炎患者和2009年大流行期间确诊的50名AH 1 N1肺炎患者进行了回顾性比较。两名放射科医生独立和盲法审查胸部CT扫描，通过协商解决不一致问题。记录高密度病变内的扩张或迂曲血管。COVID-19肺炎表现为双侧（96%）、GGO周边区域（22%）、实变（4%）或合并GGO实变（74%）。COVID-19肺炎中的血管扩张体征在COVID-19（45/50，90%）中比AH 1 N1肺炎（12/50，24%）更常见（p < 0.001）。血管扩张多见于下叶，呈周边分布。实变/GGO区域的血管扩大可能是COVID-19患者中相当常见的早期CT标志物，并且病因不确定。虽然是推测性的，但理论机制可能反映急性炎症变化、肺内皮活化或急性停滞。进一步的研究是必要的，以验证特异性和研究，如果预后的临床结果。COVID-19; SARS-CoV-2; AH 1 N1流感;胸部计算机断层扫描;血管增大
To investigate the early CT findings in COVID-19 pneumonia as compared to influenza A virus H1N1 (AH1N1), with focus on vascular enlargement within consolidation or ground glass opacity (GGO) areas. 50 patients with COVID-19 pneumonia were retrospectively compared to 50 patients with AH1N1 pneumonia diagnosed during the 2009 pandemic. Two radiologists reviewed chest CT scans independently and blindly, with discordance resolved by consensus. Dilated or tortuous vessels within hyperdense lesions were recorded. COVID-19 pneumonia presented with bilateral (96%), peripheral areas of GGO (22%), consolidation (4%) or combined GGO-consolidation (74%). The vascular enlargement sign in COVID-19 pneumonia was much more commonly present in COVID-19 (45/50, 90%) versus AH1N1 pneumonia (12/50, 24%) (p < 0.001). Vascular enlargement was more often present in lower lobes with a peripheral distribution. Vascular enlargement in consolidative/GGO areas may represent a reasonably common early CT marker in COVID-19 patients and is of uncertain etiology. Although speculative, theoretical mechanisms could potentially reflect acute inflammatory changes, pulmonary endothelial activation, or acute stasis. Further studies are necessary to verify specificity and to study if prognostic for clinical outcomes. COVID-19; SARS-CoV-2; AH1N1 influenza; Chest computed tomography; Vascular enlargement
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