Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
复制标题
抑制脂氧合酶（LOX）或环氧合酶（COX）可改善内毒素休克大鼠的存活率。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. Scheuch
中科院分区：
文献类型：
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作者：
U. Schaper;G. Lueddeckens;W. Förster;D. Scheuch
在一个明确的内毒素（ET）休克模型中，我们比较了选择性LOX抑制剂FLM 5011和COX抑制剂乙酰水杨酸（阿萨）对存活率的影响，以及对TXB 2和6-oxo-PGF 1的影响，并对休克综合征的选定参数进行了表征。两种物质的预处理降低了致死率。TXB 2和PGF 1浓度在治疗干预后均未显示出一致的趋势。没有一个被调查的介质可以被确定为主要的“休克介质”。
In a well defined endotoxin (ET) shock model we compared the influence of a selective LOX-inhibitor FLM 5011 and the COX-inhibitor Acetylsalicylic acid (ASA) on survival as well as on their effects on TXB2 and 6-oxo-PGF1 and on selected parameters characterizing the shock syndrome. Pretreatment with both substances reduced the lethality rate. Neither TXB2 nor the PGF1 concentration revealed a consistent trend after therapeutic intervention. None of the investigated mediators could be identified as the primary "shock mediator".