Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N‐methyl‐d‐aspartic acid receptors in erectile function
Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N‐methyl‐d‐aspartic acid receptors in erectile function
复制标题
性活动时雄性大鼠室旁核细胞外兴奋性氨基酸增加：N-甲基-d-天冬氨酸受体在勃起功能中的主要作用
DOI：
10.1111/j.0953-816x.2004.03362.x
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
A. Argiolas
中科院分区：
文献类型：
--
作者：
M. R. Melis;S. Succu;M. Mascia;Luca Cortis;A. Argiolas
在性欲强的雄性大鼠性活动过程中，将垂直微透析探头植入下丘脑室旁核，测定其透析液中谷氨酸和天冬氨酸的浓度。当动物被放在一只能接受(去卵巢的雌激素和黄体酮)的雌性大鼠面前并与之交配时，动物表现出非接触性勃起。与受体雌性大鼠接触时，脑室旁透析液中谷氨酸和天冬氨酸的浓度分别增加了37%和80%，交配时分别增加了55%和127%。当性欲旺盛的雄性大鼠暴露于不接受(去势而不是雌激素和孕激素)的雌性大鼠或使用阳萎雄性大鼠时，脑室旁透析液中谷氨酸和天冬氨酸的浓度没有变化。非竞争性N-甲基-d-天冬氨酸受体拮抗剂兴奋性氨基酸受体拮抗剂地佐西平(5 µg)可减少非接触性勃起，显著降低交配活动。α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic酸受体拮抗剂6-氰基-7-硝基-2，3-二酮(5 µg)也能抑制交配活动，但程度比地佐西平低得多。相反，代谢性受体拮抗剂(±)-2-氨基-4-膦-丁酸(5 µg)则无效。这些结果证实了室旁核参与了勃起功能和交配行为的控制，并表明在生理环境中，当阴茎勃起时，室旁核兴奋性氨基酸浓度增加。
The concentrations of glutamic and aspartic acids were measured in the dialysate obtained with vertical microdialysis probes implanted into the paraventricular nucleus of the hypothalamus of sexually potent male rats during sexual activity. Animals showed noncontact erections when put in the presence of, and copulated with, a receptive (ovarietomized oestrogen‐ and progesterone‐primed) female rat. The concentrations of glutamic and aspartic acids in the paraventricular dialysate increased by 37 and 80%, respectively, above baseline values during exposure to the receptive female rat and by 55 and 127%, respectively, during copulation. No changes in the concentrations of glutamic and aspartic acids were detected in the paraventricular dialysate when sexually potent male rats were exposed to nonreceptive (ovariectomized not oestrogen‐ and progesterone‐primed) female rats or when impotent male rats were used. The injection into the paraventricular nucleus of the excitatory amino acid receptor antagonist dizocilpine (5 µg), a noncompetitive N‐methyl‐d‐aspartic acid receptor antagonist, reduced noncontact erections and significantly impaired copulatory activity. The α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid receptor antagonist 6‐cyano‐7‐nitro‐quinoxaline‐2,3‐dione (5 µg) was also able to impair copulatory activity, but to a much lower extent than dizocilpine. In contrast, (±)‐2‐amino‐4‐phosphono‐butanoic acid, a metabotropic receptor antagonist (5 µg), was found to be ineffective. These results confirm the involvement of the paraventricular nucleus in the control of erectile function and copulatory behaviour and show that excitatory amino acid concentration increases in the paraventricular nucleus when penile erection occurs in physiological contexts.
阴茎勃起的中枢控制。
DOI：
--
发表时间：
1998
期刊：
International journal of impotence research.
影响因子：
--
作者：
McKenna,KE
通讯作者：
McKenna,KE
阿朴吗啡和 D2 受体激动剂对雄性和雌性猴子血浆中催产素浓度的多巴胺能刺激。
DOI：
10.1210/jcem.75.3.1355489
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Cameron,JL;Pomerantz,SM;Layden,LM;Amico,JA
通讯作者：
Amico,JA