varLD: a program for quantifying variation in linkage disequilibrium patterns between populations
varLD: a program for quantifying variation in linkage disequilibrium patterns between populations
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DOI：
10.1093/bioinformatics/btq125
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发表时间：
2010-05-01
期刊：
影响因子：
5.8
通讯作者：
Teo, Yik-Ying
中科院分区：
文献类型：
--
作者：
Ong, Rick Twee-Hee;Teo, Yik-Ying
动机：群体间的连锁不平衡（LD）差异可能导致独立全基因组关联研究（GWAS）中无法复制性状关联的主要信号。然而，可以利用这种群体间LD差异来缩小对负责观察到的关联信号的常见因果变体的搜索。因此，评估和量化群体间LD变异的能力预计将有助于复制和。GWAS的新映射阶段。
Motivation: Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and quantify LD variations among populations is thus expected to contribute to both replication and. ne-mapping stages of GWAS.