EFFECT OF HUMAN LEUKOCYTE INTERFERON ON HEPATITIS B VIRUS-INFECTION IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS
EFFECT OF HUMAN LEUKOCYTE INTERFERON ON HEPATITIS B VIRUS-INFECTION IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS
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DOI：
10.1056/nejm197609022951001
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发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
MERIGAN, TC
中科院分区：
文献类型：
--
作者：
GREENBERG, HB;POLLARD, RB;MERIGAN, TC
应用人白细胞干扰素治疗慢性乙型肝炎和慢性活动性肝炎。其中三人的循环丹麦颗粒标志物水平持续升高，包括丹麦颗粒相关DNA聚合酶活性、乙型肝炎核心抗原和丹麦颗粒相关DNA。注射干扰素的剂量在6.0倍之间。103次和17次。在三名患者中，每天104 U/kg与所有丹麦颗粒标记物的快速和可重复性下降有关。当干扰素给药10天或更短时间时，抑制作用是短暂的，但当给药时间延长一个月或更长时间时，抑制作用似乎更持久。长期干扰素治疗与3例患者中2例乙型肝炎表面抗原显著下降，2例患者中2例e抗原消失相关。干扰素可用于限制携带者的传染性或根除慢性感染。
For patients with chronic hepatitis B infection and chronic active hepatitis were treated with human leukocyte interferon. Three of them had consistently elevated levels of circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, hepatitis B core antigen and Dane-particle-associated DNA. Parenteral interferon administration at a dosage between 6.0 .times. 103 and 17 .times. 104 U/kg per day was associated with a rapid and reproducible fall in all Dane-particle markers in the three patients. The suppressive effect was transient when the interferon was given for 10 days or less, but appeared to be more permanent when administration was prolonged for a month or more. Long-term interferon therapy was associated with a marked fall in hepatitis B surface antigen in 2 of 3 patients, and a disappearance of e antigen in 2 of 2 patients. Interferon may be useful in limiting carrier infectivity or eradicating chronic infection.