Diffusion tensor MRI in temporal lobe epilepsy
Diffusion tensor MRI in temporal lobe epilepsy
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DOI：
10.1016/s0730-725x(02)00509-x
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发表时间：
2002-09-01
影响因子：
2.5
通讯作者：
Meyerand, ME
中科院分区：
文献类型：
--
作者：
Arfanakis, K;Hermann, B;Meyerand, ME
本研究旨在探讨局灶性颞叶癫痫（TLE）患者脑白质的扩散特征。应用弥散张量成像（Diffusion tensor imaging， DTI）对患者和正常对照进行观察。计算了所有受试者的旋转不变平均扩散率和扩散各向异性图。两组之间进行了几个白质结构的比较。每个选定结构的平均扩散率和扩散各向异性与癫痫发病年龄和持续时间的相关性进行了测试。与对照组相比，在患者的几个白质结构中检测到明显降低的扩散各向异性和垂直于轴突方向的较高扩散率。这些结构并不位于颞叶。两组所选结构的平均扩散率无显著差异。脑后胼胝体扩散各向异性与癫痫发病年龄显著相关。癫痫持续时间与所选结构的弥散指数无显著相关。本研究结果表明，扩散各向异性可能揭示局灶性TLE患者的异常。此外，这些异常变化并不一定局限于颞叶，也可能延伸到大脑的其他区域。此外，癫痫发作的年龄可能是决定癫痫对白质影响程度的重要因素。(C) 2002爱思唯尔科学有限公司版权所有。
The purpose of this study was to investigate the diffusion characteristics of white matter in patients with focal temporal lobe epilepsy (TLE). Diffusion tensor imaging (DTI) was applied to patients and normal controls. Rotationally invariant mean diffusivity and diffusion anisotropy maps were calculated for all subjects. Comparisons between the two groups were performed for several white matter structures. Mean diffusivity and diffusion anisotropy of each selected structure were tested for correlations with age at onset and duration of epilepsy. Significantly lower diffusion anisotropy, and higher diffusivity in directions perpendicular to the axons, was detected in several white matter structures of the patients when compared to the controls. These structures were not located in the temporal lobes. No significant difference in mean diffusivity was detected between the selected structures from the two groups. Diffusion anisotropy was significantly correlated with age at onset of epilepsy in the posterior corpus callosum. Duration of epilepsy was not significantly correlated with the diffusion indices from any of the selected structures. The results of this study suggest that diffusion anisotropy may reveal abnormalities in patients with focal TLE. In addition, these abnormal changes are not necessarily restricted to the temporal lobes but might extend in other brain regions as well. Furthermore, the age at onset of epilepsy may be an important factor in determining the extent of the effect of epilepsy on white matter. (C) 2002 Elsevier Science Inc. All rights reserved.