Neural correlates of processing emotional prosody in unipolar depression
Neural correlates of processing emotional prosody in unipolar depression
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DOI：
10.1002/hbm.24185
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发表时间：
2018-08
影响因子：
4.8
通讯作者：
K. Koch;Sophia Stegmaier;Lena Schwarz;M. Erb;M. Reinl;K. Scheffler;D. Wildgruber;T. Ethofer
中科院分区：
文献类型：
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作者：
K. Koch;Sophia Stegmaier;Lena Schwarz;M. Erb;M. Reinl;K. Scheffler;D. Wildgruber;T. Ethofer
重度抑郁障碍（MDD）的特征是有偏见的情绪感知。在听觉领域，重度抑郁症患者对言语旋律（韵律）表达的积极情绪的处理减弱。到目前为止，还没有神经影像学研究可以检验重度抑郁症情绪韵律加工改变的神经基础。在本研究中，我们通过在功能磁共振成像（fMRI）中使用李克特五分制评估快乐、中性和愤怒韵律刺激时MDD患者的情绪偏差来解决这一问题。正如预期的那样，重度抑郁症患者对快乐韵律的评价低于健康对照组（HC）。在神经水平上，在处理情绪韵律时，所有参与者的颞上回（STG）和杏仁核的激活都比处理中性韵律时强。MDD患者在处理韵律时表现出杏仁核的激活增加，与价无关，而STG在两组之间没有显著差异，这表明MDD患者对韵律情绪的处理改变发生在杏仁核而不是听觉区域。与对积极韵律刺激的减弱评价的价特异性行为效应一致，重度抑郁症患者左杏仁核的激活与快乐韵律评分相关，但与中性或愤怒韵律评分无关。我们的研究首次揭示了积极信息体验减少和韵律处理过程中杏仁核活动异常增加的神经基础。
Major depressive disorder (MDD) is characterized by a biased emotion perception. In the auditory domain, MDD patients have been shown to exhibit attenuated processing of positive emotions expressed by speech melody (prosody). So far, no neuroimaging studies examining the neural basis of altered processing of emotional prosody in MDD are available. In this study, we addressed this issue by examining the emotion bias in MDD during evaluation of happy, neutral, and angry prosodic stimuli on a five‐point Likert scale during functional magnetic resonance imaging (fMRI). As expected, MDD patients rated happy prosody less intense than healthy controls (HC). At neural level, stronger activation in the middle superior temporal gyrus (STG) and the amygdala was found in all participants when processing emotional as compared to neutral prosody. MDD patients exhibited an increased activation of the amygdala during processing prosody irrespective of valence while no significant differences between groups were found for the STG, indicating that altered processing of prosodic emotions in MDD occurs rather within the amygdala than in auditory areas. Concurring with the valence‐specific behavioral effect of attenuated evaluation of positive prosodic stimuli, activation within the left amygdala of MDD patients correlated with ratings of happy, but not neutral or angry prosody. Our study provides first insights in the neural basis of reduced experience of positive information and an abnormally increased amygdala activity during prosody processing.