Cell Death during Early Morphogenesis: Parallels between Insect Limb and Vertebrate Limb Development
Cell Death during Early Morphogenesis: Parallels between Insect Limb and Vertebrate Limb Development
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早期形态发生过程中的细胞死亡：昆虫肢体和脊椎动物肢体发育之间的相似之处
作者：
J. Whitten
成蝇复杂的关节腿是在蛹阶段从一个简单的分叶细胞囊中衍生而来的。导致成体形状的大体形态变化是由细胞的差异生长和大量成人盘细胞的程序性死亡共同作用的。这些事件与脊椎动物形态发生过程中的手指形成和肢体轮廓非常相似。在这两种情况下，吞噬血细胞都密切相关。
The complex jointed leg of the adult fly is derived, in the pupal stage, from a simple lobed sac of cells. The gross morphological changes that result in adult shape are effected by a combination of differential cell growth and the programmed death of a large number of imaginal disc cells. Events are closely similar to those occurring in digit formation and limb contouring during vertebrate morphogenesis. In both cases phagocytic blood cells are intimately involved.