Electrocerebral activity and epileptic attacks at various blood sugar levels
Electrocerebral activity and epileptic attacks at various blood sugar levels
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DOI：
10.1007/bf01232695
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Rudolf Engel M. D.;F. Halberg;F. Tichy;R. Dow
中科院分区：
文献类型：
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作者：
Rudolf Engel M. D.;F. Halberg;F. Tichy;R. Dow
本文首先结合文献，对血糖与脑电波的关系及不同血糖水平下癫痫发作的发生率等问题进行了综述，并对1例儿童糖尿病合并癫痫的病例进行了介绍。对这名患者的临床观察，这是早些时候发表的，在这里与病理结果相结合。再次强调外源性高胰岛素血症在引起癫痫中所起的作用，然后给出在几个24小时内对报告病例进行的概况研究的结果，并结合统计分析的摘要。这些结果揭示了脑电图2.5/s波和棘波与血糖水平之间的显著正相关。还注意到，尽管胰岛素给药后的低血糖可能通过脑损伤引起癫痫，但在这种受损的脑中促使癫痫发作的机制本身既不是低血糖也不是高血糖。
Several aspecls of our present knowledge on (A) the relations of blood sugar to brain waves and on (B) the occurrence of epileptic attacks at different blood sugar levels are summarized first with reference to the literature.A case report on a child with diabetes and epilepsy is presented next. Clinical observations on this patient, which were published earlier, are integrated herein with the pathological findings. The role played by exogenous hyperinsulinism in bringing about epilepsy is reemphasized.The results of profile studies carried out during several 24,hour periods on the case reported are then given, in conjunction with a summary of statistical analyses. These results reveal a significant positive correlation between the electroencephalographic 21/2 per second wave and spike on one hand and the blood sugar level on the other. It is also noted, that whereas hypoglycemia subsequent to insulin administration may give rise to epilepsy by brain damage, the mechanism which precipitates seizures in such a damaged brain is neither hypoglycemia nor hyperglycemia, per se.