La2O3 nanoparticle/polyacrylonitrile nanofibers for bacterial inactivation based on phosphate control
La2O3 nanoparticle/polyacrylonitrile nanofibers for bacterial inactivation based on phosphate control
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La2O3纳米粒子/聚丙烯腈纳米纤维用于基于磷酸盐控制的细菌灭活
DOI：
10.1039/c6ra22374e
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Cui, Fuyi
中科院分区：
文献类型：
--
作者：
He, Jiaojie;Wang, Wei;Cui, Fuyi
采用静电纺丝法制备了La_2O_3纳米粒子掺杂聚丙烯腈纳米纤维毡。在形成过程中，PAN纳米纤维作为载体固定了La2O_3纳米粒子。由于PAN纳米纤维具有很强的亲水性和磷酸盐/镧键的化学亲和力，功能性复合纳米纤维垫对磷酸盐具有很高的去除能力，最大吸附容量为77.76 mg P/g(La)，这保证了严重的缺磷条件。有效营养(磷酸盐)饥饿和大肠杆菌与复合体的紧密接触都能产生很强的抗菌活性。营养饥饿(间接抗菌)被证明是主要机制。亲密接触(直接抗菌)被揭示为辅助作用，仅在没有磷酸盐存在的情况下诱导细胞死亡。结果表明，该抗菌策略通过磷饥饿的方法是可行的。此外，复合纳米纤维垫具有制备简单、使用后易从非均相体系中分离等优点，具有实际应用价值。
La2O3 nanoparticle-doped PAN nanofiber mats were prepared by an electrospinning process. During the formation process, PAN nanofibers served as the matrix for immobilizing the La2O3 nanoparticles. Due to the great hydrophilicity of PAN nanofibers and the strong chemical affinity of phosphate/lanthanum bonds, the functional composite nanofiber mats exhibited high removal capacity for phosphate with a maximum adsorption capacity of 77.76 mg P per g (La), which guaranteed severe phosphate-deficient conditions. The effects of both the effective nutrient (phosphate) starvation and the close contact of E. coli with composites led to great antibacterial activity. The nutrient starvation (indirect antibacteria) was proved to be the primary mechanism. The intimate contact (direct antibacteria) was revealed as a supplementary role that only induced cell death without the existence of phosphate. The results demonstrated the feasibility of this antibacterial strategy through phosphate-starvation. In addition, the composite nanofiber mats implied a practical application by virtue of a simple fabrication and easy separation from the heterogeneous systems after using.