Serum Leptin, Energy Budget, and Thermogenesis in Striped Hamsters Exposed to Consecutive Decreases in Ambient Temperatures
Serum Leptin, Energy Budget, and Thermogenesis in Striped Hamsters Exposed to Consecutive Decreases in Ambient Temperatures
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环境温度连续降低的条纹仓鼠的血清瘦素、能量预算和生热作用
DOI：
10.1086/662553
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发表时间：
2011-10
影响因子：
1.6
通讯作者：
Zhao, Zhi-Jun
中科院分区：
文献类型：
--
作者：
Zhao, Zhi-Jun
在体重（Mb）和脂肪量呈现季节性下降的小型哺乳动物中，瘦素已被发现直接参与能量摄入和能量消耗的调节，但它在一种表现出季节性产热增加的动物中的作用（未完整表述，句子似乎不完整）
Leptin has been found to be a direct participant in the regulation of both energy intake and energy expenditure in small mammals showing seasonal declines in body mass (Mb) and fat mass, but its roles in an animal exhibiting seasonally increased thermogenesis and unchanged Mb remain unclear. Serum leptin levels, energy budget, and thermogenesis were measured in striped hamsters exposed to consecutive decreases in ambient temperatures ranging from 23° to −23°C. Cold-exposed hamsters had significant increases in gross energy intake (GEI), the rate of basal metabolism, nonshivering thermogenesis, and activity of cytochrome c oxidase (COX) in brown adipose tissue (BAT), compared with control hamsters, indicating a cold-induced elevation of thermogenesis. Body mass and fat content were decreased in cold-exposed animals, and serum leptin levels were increased in hamsters exposed to temperatures of −8°C and below in inverse proportion to body fat content. Serum leptin levels were positively correlated with GEI and BAT COX activity in cold-exposed hamsters, but no such relationships were observed in control animals. These findings suggest that cold-exposed hamsters increase food consumption to meet the energy requirements for increased BAT thermogenesis. The increases in serum leptin levels are likely involved in increased thermogenesis in hamsters under cold stress. Cold-exposed hamsters may become leptin resistant, which is associated with impaired regulation of food intake. This new natural model of leptin resistance may also provide insight into the dynamic long-term control of energy homeostasis for animals that do not exhibit seasonal decline in Mb.
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影响因子：
2.7
作者：
J. Weiner
通讯作者：
J. Weiner
DOI：
10.1007/s00360-010-0476-8
发表时间：
2010-05
期刊：
Journal of Comparative Physiology B
影响因子：
--
作者：
T. Ruf;B. Grafl
通讯作者：
T. Ruf;B. Grafl
影响因子：
1.6
作者：
Zhijun Zhao;Dehua Wang
通讯作者：
Zhijun Zhao;Dehua Wang
DOI：
10.1016/j.cbpa.2009.05.004
发表时间：
2009-09
期刊：
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子：
--
作者：
Zhijun Zhao;Jing Cao
通讯作者：
Zhijun Zhao;Jing Cao
影响因子：
2.7
作者：
Zhiyuan Song;Dehua Wang
通讯作者：
Zhiyuan Song;Dehua Wang