Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats: a case-control study
Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats: a case-control study
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DOI：
10.1051/vetres/2010028
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发表时间：
2010-09-01
影响因子：
4.4
通讯作者：
Pfeiffer, Dirk Udo
中科院分区：
文献类型：
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作者：
Magalhaes, Ricardo Jorge Soares;Loeffler, Anette;Pfeiffer, Dirk Udo
在一项不匹配的病例对照研究中，对犬和猫感染耐甲氧西林金黄色葡萄球菌（MRSA）的危险因素进行了研究。来自英国150家兽医诊所的197只动物共入组，包括105例MRSA病例和92例甲氧西林敏感性S.金黄色葡萄球菌（MSSA）感染。使用logistic回归将动物主人和兽医工作人员与人类医疗保健部门（HCS）的关联以及动物相关特征（如显著性、抗菌和免疫抑制治疗以及手术）作为推定的风险因素进行评价。我们发现，MRSA感染的重要风险因素是抗菌疗程数（p = 0.005）、兽医诊所住院天数（p = 0.003）和接受外科植入物（p = 0.001）。此外，MRSA感染的宠物与患病并入院的人接触的几率（p = 0.062）高于MSSA对照。在这项研究中确定的风险因素强调，需要提高警惕，识别伴侣动物群体的风险，并倡导负责任和明智地使用抗菌药物的小动物的做法。
Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats were investigated in an unmatched case-control study. A total of 197 animals from 150 veterinary practices across the United Kingdom was enrolled, including 105 MRSA cases and 92 controls with methicillin-susceptible S. aureus (MSSA) infection. The association of owners and veterinarian staff with the human healthcare sector (HCS) and animal-related characteristics such as signalment, antimicrobial and immunosuppressive therapy, and surgery were evaluated as putative risk factors using logistic regression. We found that significant risk factors for MRSA infection were the number of antimicrobial courses (p = 0.005), number of days admitted to veterinary clinics (p = 0.003) and having received surgical implants (p = 0.001). In addition, the odds of contact with humans which had been ill and admitted to hospital (p = 0.062) were higher in MRSA infected pets than in MSSA controls. The risk factors identified in this study highlight the need to increase vigilance towards identification of companion animal groups at risk and to advocate responsible and judicious use of antimicrobials in small animal practice.